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  • Revisiting the role of histo-blood group antigens in rotavirus host-cell invasion

    Author(s)
    Boehm, Raphael
    Fleming, Fiona E
    Maggioni, Andrea
    Dang, Vi T
    Holloway, Gavan
    Coulson, Barbara S
    von Itzstein, Mark
    Haselhorst, Thomas
    Griffith University Author(s)
    von Itzstein, Mark
    Haselhorst, Thomas E.
    Coulson, Barbara
    Maggioni, Andrea
    Bohm, Raphael
    Year published
    2015
    Metadata
    Show full item record
    Abstract
    Histo-blood group antigens (HBGAs) have been proposed as rotavirus receptors. H type-1 and Lewisb antigens have been reported to bind VP8* from major human rotavirus genotypes P[4], P[6] and P[8], while VP8* from a rarer P[14] rotavirus recognizes A-type HBGAs. However, the role and significance of HBGA receptors in rotavirus pathogenesis remains uncertain. Here we report that P[14] rotavirus HAL1166 and the related P[9] human rotavirus K8 bind to A-type HBGAs, although neither virus engages the HBGA-specific a1,2-linked fucose moiety. Notably, human rotaviruses DS-1 (P[4]) and RV-3 (P[6]) also use A-type HBGAs for infection, ...
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    Histo-blood group antigens (HBGAs) have been proposed as rotavirus receptors. H type-1 and Lewisb antigens have been reported to bind VP8* from major human rotavirus genotypes P[4], P[6] and P[8], while VP8* from a rarer P[14] rotavirus recognizes A-type HBGAs. However, the role and significance of HBGA receptors in rotavirus pathogenesis remains uncertain. Here we report that P[14] rotavirus HAL1166 and the related P[9] human rotavirus K8 bind to A-type HBGAs, although neither virus engages the HBGA-specific a1,2-linked fucose moiety. Notably, human rotaviruses DS-1 (P[4]) and RV-3 (P[6]) also use A-type HBGAs for infection, with fucose involvement. However, human P[8] rotavirus Wa does not recognize A-type HBGAs. Furthermore, the common human rotaviruses that we have investigated do not use Lewisb and H type-1 antigens. Our results indicate that A-type HBGAs are receptors for human rotaviruses, although rotavirus strains vary in their ability to recognize these antigens.
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    Journal Title
    Nature Communications
    Volume
    6
    DOI
    https://doi.org/10.1038/ncomms6907
    Subject
    Receptors and Membrane Biology
    Publication URI
    http://hdl.handle.net/10072/102450
    Collection
    • Journal articles

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