Revisiting the role of histo-blood group antigens in rotavirus host-cell invasion
Author(s)
Boehm, Raphael
Fleming, Fiona E
Maggioni, Andrea
Dang, Vi T
Holloway, Gavan
Coulson, Barbara S
von Itzstein, Mark
Haselhorst, Thomas
Griffith University Author(s)
Year published
2015
Metadata
Show full item recordAbstract
Histo-blood group antigens (HBGAs) have been proposed as rotavirus receptors. H type-1
and Lewisb antigens have been reported to bind VP8* from major human rotavirus genotypes
P[4], P[6] and P[8], while VP8* from a rarer P[14] rotavirus recognizes A-type HBGAs.
However, the role and significance of HBGA receptors in rotavirus pathogenesis remains
uncertain. Here we report that P[14] rotavirus HAL1166 and the related P[9] human rotavirus
K8 bind to A-type HBGAs, although neither virus engages the HBGA-specific a1,2-linked
fucose moiety. Notably, human rotaviruses DS-1 (P[4]) and RV-3 (P[6]) also use A-type
HBGAs for infection, ...
View more >Histo-blood group antigens (HBGAs) have been proposed as rotavirus receptors. H type-1 and Lewisb antigens have been reported to bind VP8* from major human rotavirus genotypes P[4], P[6] and P[8], while VP8* from a rarer P[14] rotavirus recognizes A-type HBGAs. However, the role and significance of HBGA receptors in rotavirus pathogenesis remains uncertain. Here we report that P[14] rotavirus HAL1166 and the related P[9] human rotavirus K8 bind to A-type HBGAs, although neither virus engages the HBGA-specific a1,2-linked fucose moiety. Notably, human rotaviruses DS-1 (P[4]) and RV-3 (P[6]) also use A-type HBGAs for infection, with fucose involvement. However, human P[8] rotavirus Wa does not recognize A-type HBGAs. Furthermore, the common human rotaviruses that we have investigated do not use Lewisb and H type-1 antigens. Our results indicate that A-type HBGAs are receptors for human rotaviruses, although rotavirus strains vary in their ability to recognize these antigens.
View less >
View more >Histo-blood group antigens (HBGAs) have been proposed as rotavirus receptors. H type-1 and Lewisb antigens have been reported to bind VP8* from major human rotavirus genotypes P[4], P[6] and P[8], while VP8* from a rarer P[14] rotavirus recognizes A-type HBGAs. However, the role and significance of HBGA receptors in rotavirus pathogenesis remains uncertain. Here we report that P[14] rotavirus HAL1166 and the related P[9] human rotavirus K8 bind to A-type HBGAs, although neither virus engages the HBGA-specific a1,2-linked fucose moiety. Notably, human rotaviruses DS-1 (P[4]) and RV-3 (P[6]) also use A-type HBGAs for infection, with fucose involvement. However, human P[8] rotavirus Wa does not recognize A-type HBGAs. Furthermore, the common human rotaviruses that we have investigated do not use Lewisb and H type-1 antigens. Our results indicate that A-type HBGAs are receptors for human rotaviruses, although rotavirus strains vary in their ability to recognize these antigens.
View less >
Journal Title
Nature Communications
Volume
6
Subject
Receptors and Membrane Biology