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dc.contributor.authorGasparini, Claudia
dc.contributor.authorSutherland, Heidi G.
dc.contributor.authorMaher, Bridget
dc.contributor.authorRodriguez-Acevedo, Astrid J.
dc.contributor.authorKhlifi, Elhame
dc.contributor.authorHaupt, Larisa M.
dc.contributor.authorGriffiths, Lyn R.
dc.date.accessioned2017-07-07T04:56:26Z
dc.date.available2017-07-07T04:56:26Z
dc.date.issued2015
dc.identifier.issn11292369
dc.identifier.doi10.1186/s10194-015-0511-y
dc.identifier.urihttp://hdl.handle.net/10072/102461
dc.description.abstractBackground: Migraine causes crippling attacks of severe head pain along with associated nausea, vomiting, photophobia and/or phonophobia. The aim of this study was to investigate single nucleotide polymorphisms (SNPs) in the adenosine deaminase, RNA-specific, B1 (ADARB1) and adenosine deaminase, RNA specific, B2 (ADARB2) genes in an Australian case–control Caucasian population for association with migraine. Both candidate genes are highly expressed in the central nervous system and fit criteria for migraine neuropathology. SNPs in the ADARB2 gene were previously found to be positively associated with migraine in a pedigree-based genome wide association study using the genetic isolate of Norfolk Island, Australia. The ADARB1 gene was also chosen for investigation due to its important function in editing neurotransmitter receptor transcripts. Methods: Four SNPs in ADARB1 and nine in ADARB2 were selected by inspecting blocks of linkage disequilibrium in Haploview for genotyping using either TaqMan or Sequenom assays. These SNPs were genotyped in two-hundred and ninety one patients who satisfied the International Classification of Headache Disorders-II 2004 diagnostic criteria for migraine, and three-hundred and fourteen controls, and PLINK was used for association testing. Results: Chi-square analysis found no significant association between any of the SNPs tested in the ADARB1 and ADARB2 genes in this study and the occurrence of migraine. Conclusions: In contrast to findings that SNPs in the ADARB2 gene were positively associated with migraine in the Norfolk Island population, we find no evidence to support the involvement of RNA editing genes in migraine susceptibility in an Australian Caucasian population.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer - Verlag Italia Srl
dc.publisher.placeItaly
dc.relation.ispartofpagefrom31-1
dc.relation.ispartofpageto31-8
dc.relation.ispartofjournalThe Journal of Headache and Pain
dc.relation.ispartofvolume16
dc.subject.fieldofresearchGenetic Immunology
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode060406
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode1103
dc.titleCase-control study of ADARB1 and ADARB2 gene variants in migraine
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2015 Gaspirini et al.; licensee Springer. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
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gro.griffith.authorGasparini, Claudia F.


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