dc.contributor.author | Tian, Li-Wen | |
dc.contributor.author | Feng, Yunjiang | |
dc.contributor.author | Tran, Trong D | |
dc.contributor.author | Shimizu, Yoko | |
dc.contributor.author | Pfeifer, Tom | |
dc.contributor.author | Forster, Paul I | |
dc.contributor.author | Quinn, Ronald J | |
dc.date.accessioned | 2017-11-28T04:30:15Z | |
dc.date.available | 2017-11-28T04:30:15Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.doi | 10.1021/acs.jnatprod.5b00211 | |
dc.identifier.uri | http://hdl.handle.net/10072/102546 | |
dc.description.abstract | Mass-directed isolation of the CH2Cl2/MeOH extract from the bark of an Australian plant, Macropteranthes leichhardtii, resulted in the purification of a new phenylpropanoid glucoside, macropteranthol (1), together with four known analogues (2–5). The structure of compound 1 was elucidated by NMR and MS data analyses and quantum chemical calculations. Compounds 3 and 5 showed inhibitory activity against tyrosyl-DNA phosphodiesterase I with IC50 values of ∼1.0 μM. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society | |
dc.publisher.place | United States | |
dc.relation.ispartofpagefrom | 1756 | |
dc.relation.ispartofpageto | 1760 | |
dc.relation.ispartofissue | 7 | |
dc.relation.ispartofjournal | Journal of Natural Products | |
dc.relation.ispartofvolume | 78 | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Other chemical sciences not elsewhere classified | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Other biological sciences not elsewhere classified | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Traditional, complementary and integrative medicine | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 349999 | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 319999 | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 4208 | |
dc.title | Tyrosyl-DNA Phosphodiesterase i Inhibitors from the Australian Plant Macropteranthes leichhardtii | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Quinn, Ronald J. | |
gro.griffith.author | Feng, Yun J. | |