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dc.contributor.authorTian, Li-Wen
dc.contributor.authorFeng, Yunjiang
dc.contributor.authorTran, Trong D
dc.contributor.authorShimizu, Yoko
dc.contributor.authorPfeifer, Tom
dc.contributor.authorForster, Paul I
dc.contributor.authorQuinn, Ronald J
dc.date.accessioned2017-11-28T04:30:15Z
dc.date.available2017-11-28T04:30:15Z
dc.date.issued2015
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/acs.jnatprod.5b00211
dc.identifier.urihttp://hdl.handle.net/10072/102546
dc.description.abstractMass-directed isolation of the CH2Cl2/MeOH extract from the bark of an Australian plant, Macropteranthes leichhardtii, resulted in the purification of a new phenylpropanoid glucoside, macropteranthol (1), together with four known analogues (2–5). The structure of compound 1 was elucidated by NMR and MS data analyses and quantum chemical calculations. Compounds 3 and 5 showed inhibitory activity against tyrosyl-DNA phosphodiesterase I with IC50 values of ∼1.0 μM.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom1756
dc.relation.ispartofpageto1760
dc.relation.ispartofissue7
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume78
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchOther chemical sciences not elsewhere classified
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchOther biological sciences not elsewhere classified
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchTraditional, complementary and integrative medicine
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode349999
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode319999
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode4208
dc.titleTyrosyl-DNA Phosphodiesterase i Inhibitors from the Australian Plant Macropteranthes leichhardtii
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorFeng, Yun J.


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