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dc.contributor.authorBerners-Price, Sue
dc.contributor.authorG. Appleton, Trevor
dc.date.accessioned2017-09-22T01:41:07Z
dc.date.available2017-09-22T01:41:07Z
dc.date.issued2000
dc.date.modified2007-03-10T07:31:25Z
dc.identifier.isbn0896035999en_US
dc.identifier.urihttp://hdl.handle.net/10072/1033
dc.description.abstractThe antitumor properties of platinum-containing drugs are attributable in large measure to the kinetics of their ligand displacement reactions. As is discussed at length in other contributions to this volume, their primary target is believed to be nitrogen donor atoms in the nucleobases of DNA. The bonds formed between the metal ion and these atoms must be sufficiently long-lived to interfere with the process of cell division, or to trigger the intracellular mechanisms that recognize irreparable damage to a cell. Bonds between the nucleobase nitrogen atoms and platinum(II) clearly fulfil this requirement. Metal ions that form labile bonds with the nucleobase nitrogen atoms cannot act in a similar way and do not give active compounds (1).en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherHumana Pressen_US
dc.publisher.placeTotowa,NewJersey USAen_US
dc.publisher.urihttps://link.springer.com/chapter/10.1007/978-1-59259-012-4_1en_US
dc.relation.ispartofbooktitlePlatinum-Based Drugs in Cancer Therapyen_US
dc.relation.ispartofpagefrom3en_US
dc.relation.ispartofpageto35en_US
dc.subject.fieldofresearchHISTORY AND ARCHAEOLOGYen_US
dc.subject.fieldofresearchcode210000en_US
dc.titleThe Chemistry of Cisplatin in Aqueous Solutionen_US
dc.typeBook chapteren_US
dc.type.descriptionB1 - Book Chapters (HERDC)en_US
dc.type.codeB - Book Chaptersen_US
gro.facultyOffice of the Snr Dep Vice Chancellor, Institute for Glycomicsen_US
gro.date.issued2000
gro.hasfulltextNo Full Text


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