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dc.contributor.authorY. Wang, Claire
dc.contributor.authorD. Nguyen, Nguyen
dc.contributor.authorMorrison, Nigel
dc.contributor.authorA. Eisman, John
dc.contributor.authorR. Center, Jacqueline
dc.contributor.authorV. Nguyen, Tuan
dc.contributor.editorDeborah Saltman
dc.date.accessioned2017-08-10T23:56:58Z
dc.date.available2017-08-10T23:56:58Z
dc.date.issued2006
dc.date.modified2007-08-17T06:42:19Z
dc.identifier.issn1471-2350en_US
dc.identifier.doi10.1186/1471-2350-7-57en_US
dc.identifier.urihttp://hdl.handle.net/10072/11261
dc.description.abstractBackground: Recent studies have suggested that the Arg allele of β3-adrenergic receptor (ADRB3) gene is associated with body mass index (BMI), which is an important predictor of bone mineral density (BMD) and fracture risk. However, whether the ADRB3 gene polymorphism is associated with fracture risk has not been investigated. The aim of study was to examine the inter-relationships between ADRB3 gene polymorphisms, BMI, BMD and fracture risk in elderly Caucasians. Methods: Genotypes of the ADRB3 gene were determined in 265 men and 446 women aged 60+ in 1989 at entry into the study, whose BMD were measured by DXA (GE Lunar, WI USA) at baseline. During the follow-up period (between 1989 and 2004), fractures were ascertained by reviewing radiography reports and personal interviews. Results: The allelic frequencies of the Trp and the Arg alleles were 0.925 and 0.075 respectively, and the relative frequencies of genotypes Trp/Trp, Trp/Arg and Arg/Arg 0.857, 0.138 and 0.006 respectively. There was no significant association between BMI and ADRB3 genotypes (p = 0.10 in women and p = 0.68 in men). There was also no significant association between ADRB3 genotypes and lumbar spine or femoral neck BMD in either men and women. Furthermore, there were no significant association between ADRB3 genotypes and fracture risk in both women and men, either before or after adjusting for and, BMD and BMI. Conclusion: The present data suggested that in Caucasian population the contribution of ADRB3 genotypes to the prediction of BMI, BMD and fracture risk is limited.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.format.extent38195 bytes
dc.format.extent304784 bytes
dc.format.mimetypetext/plain
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherBioMed Centralen_US
dc.publisher.placeEnglanden_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1en_US
dc.relation.ispartofpageto9en_US
dc.relation.ispartofissue57en_US
dc.relation.ispartofjournalBMC Medical Geneticsen_US
dc.relation.ispartofvolume7en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchcode270207en_US
dc.titleβ3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: the Dubbo Osteoporosis Epidemiology Study (DOES)en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dcterms.licensehttp://creativecommons.org/licenses/by/2.0en_US
dc.description.versionPublisheden_US
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 57.en_US
gro.rights.copyrightCopyright 2006 Wang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited - BMC Medical Genetics 2006, 7:57- http://www.biomedcentral.com/en_US
gro.date.issued2006
gro.hasfulltextFull Text


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