• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Application of Regular Solution Theory to Solubility in Lipids and Partitioning involving Lipids

    Author(s)
    Hawker, DW
    Griffith University Author(s)
    Hawker, Darryl W.
    Year published
    1995
    Metadata
    Show full item record
    Abstract
    Expressions based on Regular Solution Theory are evaluated as a means of predicting solubilities in lipids and lipid/water partition coefficients, and confirming observed experimental trends of these parameters. Employing chlorobenzenes and chlorinated dibenzo‐p‐dioxins as solutes, and triolein as a representative lipid, it is shown that triolein/water partition coefficients (Ktw) can be expressed as a function of the solute Hildebrand parameter and molar volume. There is relatively little difference in calculated values of Ktw when a Flory‐Huggins modification is incorporated into the theoretical approach to accommodate a ...
    View more >
    Expressions based on Regular Solution Theory are evaluated as a means of predicting solubilities in lipids and lipid/water partition coefficients, and confirming observed experimental trends of these parameters. Employing chlorobenzenes and chlorinated dibenzo‐p‐dioxins as solutes, and triolein as a representative lipid, it is shown that triolein/water partition coefficients (Ktw) can be expressed as a function of the solute Hildebrand parameter and molar volume. There is relatively little difference in calculated values of Ktw when a Flory‐Huggins modification is incorporated into the theoretical approach to accommodate a molecular size disparity between solutes and triolein. Results confirm that the relationship between log Ktw and the logarithm of the octan‐1‐ol/water partition coefficient (log KowJ is slightly curvilinear due to increasing solute non‐ideality in triolein, demonstrating the utility of this theoretical approach. Regular Solution Theory is also shown to be useful for predicting solubilities in lipids such as triolein. Liquid and supercooled liquid solubility of chlorobenzenes and chlorinated dibenzo‐p‐dioxins in triolein decrease with solute size, molar volume or log Kow value. When supercooled data is converted into lipid solubility of solid material, the decrease is even more pronounced. These trends alone, however, cannot account for observed decreasing bioconcentration factors with relatively large, hydrophobic solutes.
    View less >
    Journal Title
    Toxicological and Environmental Chemistry
    Volume
    50
    DOI
    https://doi.org/10.1080/02772249509358203
    Subject
    Chemical sciences
    Publication URI
    http://hdl.handle.net/10072/120133
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander