A Comparison of the Potent Invitro Antitumour Activity of Triphenyltin Benzoates with that of Related Tin Compounds

Abstract

A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.