A Comparison of the Potent Invitro Antitumour Activity of Triphenyltin Benzoates with that of Related Tin Compounds
Author(s)
Tranter, CJ
Price, SJB
Cutts, J
Parsons, PG
Rintoul, G
Young, DJ
Griffith University Author(s)
Year published
1995
Metadata
Show full item recordAbstract
A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.
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Journal Title
Main Group Chemistry
Volume
1
Subject
Chemical sciences