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  • A Comparison of the Potent Invitro Antitumour Activity of Triphenyltin Benzoates with that of Related Tin Compounds

    Author(s)
    Tranter, CJ
    Price, SJB
    Cutts, J
    Parsons, PG
    Rintoul, G
    Young, DJ
    Griffith University Author(s)
    Parsons, Peter
    Young, David
    Berners-Price, Sue J.
    Year published
    1995
    Metadata
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    Abstract
    A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.A variety of structurally diverse triphenyltin esters exhibit almost identical in vitro antitumor activity to the potent triphenyltin benzoates and greater activity than cisplatin. This activity is independent of the structure of the ester moiety and comparable to triphenyltin hydroxide, suggesting hydrolysis to a common, cytotoxic tin intermediate.
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    Journal Title
    Main Group Chemistry
    Volume
    1
    DOI
    https://doi.org/10.1080/13583149512331338375
    Subject
    Chemical sciences
    Publication URI
    http://hdl.handle.net/10072/120241
    Collection
    • Journal articles

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