Show simple item record

dc.contributor.authorMURRELL, WG
dc.contributor.authorMASTERS, CJ
dc.contributor.authorWILLIS, RJ
dc.contributor.authorCRANE, DI
dc.date.accessioned2019-05-27T22:20:28Z
dc.date.available2019-05-27T22:20:28Z
dc.date.issued1995
dc.identifier.issn0047-6374
dc.identifier.doi10.1016/0047-6374(95)01591-M
dc.identifier.urihttp://hdl.handle.net/10072/120258
dc.description.abstractActively transcribed genes are more susceptible to nuclease digestion, an observation suggested to reflect an altered state of chromatin organization. It has been hypothesized that exposure or sequestration of chromatin domains is a higher order gene regulatory mechanism. In order to test whether tissue lineage is organized by mechanisms at the level or chromatin structure, three cardiac phenotype-conferring genes (atrial natriuretic factor, myosin light chain-1-ventricular and α-tropomyosin) have been assessed for DNase 1 sensitivity in nuclei prepared from tissues of the developing guinea pig. These data have been related to the level of tissue mRNA expression of these genes to ascertain whether the exposed state of genes can occur when transcription is low or undetectable. Although this phenomenon was evident in some cases, the data were not consistent with mechanisms at the level of chromatin structure directing tissue type.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeIreland
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto17
dc.relation.ispartofissue1
dc.relation.ispartofjournalMechanisms of Ageing and Development
dc.relation.ispartofvolume82
dc.subject.fieldofresearchInformation and computing sciences
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchcode46
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode3101
dc.titleChromatic Structure and the Expression of Cardiac Genes
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorMasters, Colin J.
gro.griffith.authorCrane, Denis I.
gro.griffith.authorWillis, Roger J.


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record