dc.contributor.author | PERKINS, AV | |
dc.contributor.author | LINTON, EA | |
dc.contributor.author | EBEN, F | |
dc.contributor.author | SIMPSON, J | |
dc.contributor.author | WOLFE, CDA | |
dc.contributor.author | REDMAN, CWG | |
dc.date.accessioned | 2019-05-27T22:07:44Z | |
dc.date.available | 2019-05-27T22:07:44Z | |
dc.date.issued | 1995 | |
dc.identifier.issn | 0306-5456 | |
dc.identifier.doi | 10.1111/j.1471-0528.1995.tb09063.x | |
dc.identifier.uri | http://hdl.handle.net/10072/120315 | |
dc.description.abstract | Objective: To measure the plasma levels of corticotrophin‐releasing hormone and corticotrophin‐releasing hormone binding protein in normal pregnancy and in pregnancies complicated by pre‐eclampsia.
Setting: John Radcliffe Hospital, Oxford and St Thomas's Hospital, London.
Subjects: One hundred and twenty pregnant women sampled prospectively throughout gestation, of whom 91 experienced a normal pregnancy and eight developed pre‐eclampsia; in a second study, 10 women with severe pre‐eclampsia, presenting at a range of gestational ages, were sampled once and compared with appropriately matched normal pregnant women.
Main outcome measure: Plasma levels of corticotrophin‐releasing hormone determined by immunoradiometric assay. Plasma levels of corticotrophin‐releasing hormone binding protein measured by direct radioimmunoassay.
Results: In the prospective study, plasma samples from women with pre‐eclampsia exhibited higher (390.2 versus 292.7 pmol/l at 36 weeks) levels of corticotrophin‐releasing hormone and significantly lower (5.24 versus 8.14 nmol/l at 36 weeks, P 0.002) levels of corticotrophin‐releasing hormone binding protein than normal controls. In the second, single time point study a significant elevation in CRH (P < 0.002) and reduction in CRH‐BP (P < 0.001) was found in pre‐eclamptic pregnancies compared with controls.
Conclusions: In human pregnancies complicated by pre‐eclampsia there is an elevated level of corticotrophin releasing hormone whilst there is less corticotrophin‐releasing hormone binding protein; therefore there is a net increase in free potentially bioactive hormone which may play a role in the pathology of the disease. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier Science | |
dc.publisher.place | UK | |
dc.relation.ispartofpagefrom | 118 | |
dc.relation.ispartofpageto | 122 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | BJOG: an International Journal of Obstetrics and Gynaecology | |
dc.relation.ispartofvolume | 102 | |
dc.subject.fieldofresearch | Technology | |
dc.subject.fieldofresearchcode | 10 | |
dc.title | Corticotrophin‐releasing hormone and corticotrophin‐ releasing hormone binding protein in normal and pre‐eclamptic human pregnancies | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Health, School of Medical Science | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Perkins, Anthony V. | |