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dc.contributor.authorPERKINS, AV
dc.contributor.authorLINTON, EA
dc.contributor.authorEBEN, F
dc.contributor.authorSIMPSON, J
dc.contributor.authorWOLFE, CDA
dc.contributor.authorREDMAN, CWG
dc.date.accessioned2019-05-27T22:07:44Z
dc.date.available2019-05-27T22:07:44Z
dc.date.issued1995
dc.identifier.issn0306-5456
dc.identifier.doi10.1111/j.1471-0528.1995.tb09063.x
dc.identifier.urihttp://hdl.handle.net/10072/120315
dc.description.abstractObjective: To measure the plasma levels of corticotrophin‐releasing hormone and corticotrophin‐releasing hormone binding protein in normal pregnancy and in pregnancies complicated by pre‐eclampsia. Setting: John Radcliffe Hospital, Oxford and St Thomas's Hospital, London. Subjects: One hundred and twenty pregnant women sampled prospectively throughout gestation, of whom 91 experienced a normal pregnancy and eight developed pre‐eclampsia; in a second study, 10 women with severe pre‐eclampsia, presenting at a range of gestational ages, were sampled once and compared with appropriately matched normal pregnant women. Main outcome measure: Plasma levels of corticotrophin‐releasing hormone determined by immunoradiometric assay. Plasma levels of corticotrophin‐releasing hormone binding protein measured by direct radioimmunoassay. Results: In the prospective study, plasma samples from women with pre‐eclampsia exhibited higher (390.2 versus 292.7 pmol/l at 36 weeks) levels of corticotrophin‐releasing hormone and significantly lower (5.24 versus 8.14 nmol/l at 36 weeks, P 0.002) levels of corticotrophin‐releasing hormone binding protein than normal controls. In the second, single time point study a significant elevation in CRH (P < 0.002) and reduction in CRH‐BP (P < 0.001) was found in pre‐eclamptic pregnancies compared with controls. Conclusions: In human pregnancies complicated by pre‐eclampsia there is an elevated level of corticotrophin releasing hormone whilst there is less corticotrophin‐releasing hormone binding protein; therefore there is a net increase in free potentially bioactive hormone which may play a role in the pathology of the disease.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeUK
dc.relation.ispartofpagefrom118
dc.relation.ispartofpageto122
dc.relation.ispartofissue2
dc.relation.ispartofjournalBJOG: an International Journal of Obstetrics and Gynaecology
dc.relation.ispartofvolume102
dc.subject.fieldofresearchTechnology
dc.subject.fieldofresearchcode10
dc.titleCorticotrophin‐releasing hormone and corticotrophin‐ releasing hormone binding protein in normal and pre‐eclamptic human pregnancies
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.hasfulltextNo Full Text
gro.griffith.authorPerkins, Anthony V.


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