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dc.contributor.authorGriffiths, Lyn
dc.contributor.authorNyholt, D.
dc.contributor.authorCurtain, R.
dc.contributor.authorGaffney, Philip
dc.contributor.authorMorris, B.
dc.date.accessioned2019-09-17T05:51:00Z
dc.date.available2019-09-17T05:51:00Z
dc.date.issued1995
dc.identifier.issn03051870
dc.identifier.doi10.1111/j.1440-1681.1995.tb02056.x
dc.identifier.urihttp://hdl.handle.net/10072/120461
dc.description.abstract1. The low density lipoprotein receptor is an important regulator of serum cholesterol which may have implications for the development of both hypertension and obesity. In this study, genotypes for a low density lipoprotein receptor gene (LDLR) dinucleotide polymorphism were determined in both lean and obese normotensive populations. 2. In previous cross-sectional association studies an ApaLI and a HincII polymorphism for LDLR were shown to be associated with obesity in essential hypertensives. However, these polymorphisms did not show an association with obesity in normotensives. 3. In contrast, this study reports that preliminary results for an LDLR microsatellite marker, located more towards the 3' end of the gene, show a significant association with obesity in the normotensive population studied. These results indicate that LDLR could play an important role in the development of obesity, which might be independent of hypertension.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.publisher.placeAustralia
dc.relation.ispartofpagefrom496
dc.relation.ispartofpageto498
dc.relation.ispartofissue6-7
dc.relation.ispartofjournalClinical and Experimental Pharmacology & Physiology
dc.relation.ispartofvolume22
dc.subject.fieldofresearchPhysiology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchMedical Physiology
dc.subject.fieldofresearchcode0606
dc.subject.fieldofresearchcode1115
dc.subject.fieldofresearchcode1116
dc.titleCross-sectional study of a microsatellite marker in the low density lipoprotein receptor gene in obese normotensives
dc.typeJournal article
dc.type.descriptionC1 - Peer Reviewed (HERDC)
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.hasfulltextNo Full Text
gro.griffith.authorGriffiths, Lyn
gro.griffith.authorGaffney, Philip T.


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