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dc.contributor.authorRedburn, Joanne
dc.contributor.authorLeah, John
dc.date.accessioned2019-05-26T22:24:01Z
dc.date.available2019-05-26T22:24:01Z
dc.date.issued1997
dc.identifier.issn03043940
dc.identifier.doi10.1016/S0304-3940(97)00820-3
dc.identifier.urihttp://hdl.handle.net/10072/120995
dc.description.abstractc-Fos expression was examined in rat brains at increasing times after a single noxious stimulus to one hindpaw. In some nuclei the expression peaked at 1 h and was gone by 6 h; in others it was biphasic with a larger peak appearing 6 h after the first. In other rats a second, contralateral stimulus was given at increasing times after the first, and c-Fos examined after a further 1.5 h. In some nuclei the first stimulus potentiated c-Fos expression caused by the second stimulus; in others the second stimulus erased any c-Fos still present from the first. Thus two similar stimuli can interact in very different ways in effecting c-Fos expression in different central nervous system nuclei, and rapid down-regulation might represent a novel type of interaction.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeIreland
dc.relation.ispartofpagefrom97
dc.relation.ispartofpageto100
dc.relation.ispartofissue2-3
dc.relation.ispartofjournalNeuroscience Letters
dc.relation.ispartofvolume237
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive Sciences
dc.subject.fieldofresearchcode1109
dc.subject.fieldofresearchcode1701
dc.subject.fieldofresearchcode1702
dc.titleAccelerated Breakdown and Enhanced Expression of c-Fos in the Rat Brain after Noxious Stimulation
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.hasfulltextNo Full Text
gro.griffith.authorLeah, John D.
gro.griffith.authorRedburn, Joanne


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