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  • The induction and potentiation of c-Jun and c-Fos expression in spinal neurons mediated by NK1 and NK2 receptors

    Author(s)
    Redburn, Joanne
    Leah, John
    Griffith University Author(s)
    Redburn, Joanne
    Leah, John D.
    Year published
    1999
    Metadata
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    Abstract
    Specific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in the deep laminae by NK2 antagonism. c-Fos induction was reduced in all laminae by both NK1 and NK2 antagonism but less than with c-Jun. The potentiation of c-Jun expression, caused by a preceding stimulus, was abolished in all laminae by NK1 and NK2 antagonists, whereas that of c-Fos was reduced in all laminae but ...
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    Specific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in the deep laminae by NK2 antagonism. c-Fos induction was reduced in all laminae by both NK1 and NK2 antagonism but less than with c-Jun. The potentiation of c-Jun expression, caused by a preceding stimulus, was abolished in all laminae by NK1 and NK2 antagonists, whereas that of c-Fos was reduced in all laminae but again less than that of c-Jun. Thus, the expressions of ITFs mediated by NK1 and NK2 receptors are complex, depending upon the neurons and stimulus considered, and they are not a measure of the neurons’ electrophysiological responsiveness.
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    Journal Title
    Neuropeptides
    Volume
    33
    Issue
    2
    DOI
    https://doi.org/10.1054/npep.1999.0005
    Subject
    Biochemistry and Cell Biology
    Clinical Sciences
    Neurosciences
    Publication URI
    http://hdl.handle.net/10072/121334
    Collection
    • Journal articles

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