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dc.contributor.authorRedburn, Joanne
dc.contributor.authorLeah, John
dc.date.accessioned2019-12-03T05:40:31Z
dc.date.available2019-12-03T05:40:31Z
dc.date.issued1999
dc.identifier.issn01434179en_US
dc.identifier.doi10.1054/npep.1999.0005en_US
dc.identifier.urihttp://hdl.handle.net/10072/121334
dc.description.abstractSpecific antagonists were used to determine NK1 and NK2 receptor mediation of the expression of c-Jun and c-Fos inducible transcription factors. (ITFs) in dorsal horn neurons. The induction of c-Jun by C-fiber stimulation was strongly reduced in the superficial laminae by NK1 and NK2 antagonists, but only weakly in the deep laminae by NK2 antagonism. c-Fos induction was reduced in all laminae by both NK1 and NK2 antagonism but less than with c-Jun. The potentiation of c-Jun expression, caused by a preceding stimulus, was abolished in all laminae by NK1 and NK2 antagonists, whereas that of c-Fos was reduced in all laminae but again less than that of c-Jun. Thus, the expressions of ITFs mediated by NK1 and NK2 receptors are complex, depending upon the neurons and stimulus considered, and they are not a measure of the neurons’ electrophysiological responsiveness.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherChurchill Livingstoneen_US
dc.publisher.placeUKen_US
dc.relation.ispartofpagefrom115en_US
dc.relation.ispartofpageto119en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalNeuropeptidesen_US
dc.relation.ispartofvolume33en_US
dc.titleThe induction and potentiation of c-Jun and c-Fos expression in spinal neurons mediated by NK1 and NK2 receptorsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, Griffith Institute for Drug Discoveryen_US
gro.hasfulltextNo Full Text
gro.griffith.authorRedburn, Joanne
gro.griffith.authorLeah, John D.


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