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dc.contributor.authorRutherford, S
dc.contributor.authorNyholt, DR
dc.contributor.authorCurtain, RP
dc.contributor.authorQuinlan, SR
dc.contributor.authorGaffney, PT
dc.contributor.authorMorris, BJ
dc.contributor.authorGriffiths, LR
dc.date.accessioned2019-09-17T05:58:25Z
dc.date.available2019-09-17T05:58:25Z
dc.date.issued1997
dc.identifier.issn0307-0565
dc.identifier.doi10.1038/sj.ijo.0800512
dc.identifier.urihttp://hdl.handle.net/10072/121459
dc.description.abstractOBJECTIVE: To determine whether a microsatellite polymorphism located towards the 3’ end of the low density lipoprotein receptor gene (LDLR) is associated with obesity. DESIGN: A cross-sectional case-control study. SUBJECTS: One hundred and seven obese individuals, defined as a body mass index (BMI)≥26 kg/m2, and 163 lean individuals, defined as a BMI<26 kg/m2. MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp). RESULTS: There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (χ2=12.3, P=0.002), but not in males (χ2=0.3, P=0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese. CONCLUSIONS: These results suggest that in females, LDLR may play a role in the development of obesity.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNature Publishing Group
dc.publisher.placeUK
dc.relation.ispartofpagefrom1032
dc.relation.ispartofpageto1037
dc.relation.ispartofissue11
dc.relation.ispartofjournalInternational Journal of Obesity
dc.relation.ispartofvolume21
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchEducation
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode39
dc.titleAssociation of a low density lipoprotein receptor microsatellite variant with obesity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorGaffney, Philip T.
gro.griffith.authorNyholt, Dale R.
gro.griffith.authorQuinlan, Sharon A.
gro.griffith.authorCurtain, Rob
gro.griffith.authorRutherford Siegel, Sue
gro.griffith.authorGriffiths, Lyn


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