dc.contributor.author | Rutherford, S | |
dc.contributor.author | Nyholt, DR | |
dc.contributor.author | Curtain, RP | |
dc.contributor.author | Quinlan, SR | |
dc.contributor.author | Gaffney, PT | |
dc.contributor.author | Morris, BJ | |
dc.contributor.author | Griffiths, LR | |
dc.date.accessioned | 2019-09-17T05:58:25Z | |
dc.date.available | 2019-09-17T05:58:25Z | |
dc.date.issued | 1997 | |
dc.identifier.issn | 0307-0565 | |
dc.identifier.doi | 10.1038/sj.ijo.0800512 | |
dc.identifier.uri | http://hdl.handle.net/10072/121459 | |
dc.description.abstract | OBJECTIVE: To determine whether a microsatellite polymorphism located towards the 3’ end of the low density lipoprotein receptor gene (LDLR) is associated with obesity. DESIGN: A cross-sectional case-control study. SUBJECTS: One hundred and seven obese individuals, defined as a body mass index (BMI)≥26 kg/m2, and 163 lean individuals, defined as a BMI<26 kg/m2. MEASUREMENTS: BMI, blood pressure, serum lipids, alleles of LDLR microsatellite (106 bp, 108 bp and 112 bp). RESULTS: There was a significant association between variants of the LDLR microsatellite and obesity, in the overall tested population, due to a contributing effect in females (χ2=12.3, P=0.002), but not in males (χ2=0.3, P=0.87). In females, individuals with the 106 bp allele were more likely to be lean, while individuals with the 112 bp and/or 108 bp alleles tended to be obese. CONCLUSIONS: These results suggest that in females, LDLR may play a role in the development of obesity. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group | |
dc.publisher.place | UK | |
dc.relation.ispartofpagefrom | 1032 | |
dc.relation.ispartofpageto | 1037 | |
dc.relation.ispartofissue | 11 | |
dc.relation.ispartofjournal | International Journal of Obesity | |
dc.relation.ispartofvolume | 21 | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Education | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 39 | |
dc.title | Association of a low density lipoprotein receptor microsatellite variant with obesity | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Gaffney, Philip T. | |
gro.griffith.author | Nyholt, Dale R. | |
gro.griffith.author | Quinlan, Sharon A. | |
gro.griffith.author | Curtain, Rob | |
gro.griffith.author | Rutherford Siegel, Sue | |
gro.griffith.author | Griffiths, Lyn | |