Show simple item record

dc.contributor.authorBenjafield, Adam
dc.contributor.authorJeyasingam, Cheryl
dc.contributor.authorNyholt, Dale
dc.contributor.authorGriffiths, Lyn
dc.contributor.authorMorris, Brian
dc.date.accessioned2019-09-17T05:14:35Z
dc.date.available2019-09-17T05:14:35Z
dc.date.issued1998
dc.identifier.issn0194911Xen_US
dc.identifier.doi10.1161/01.HYP.32.6.1094en_US
dc.identifier.urihttp://hdl.handle.net/10072/121995
dc.description.abstractEssential hypertensives display enhanced signal transduction through pertussis toxin–sensitive G proteins. The T allele of a C825T variant in exon 10 of the G protein β3 subunit gene (GNB3) induces formation of a splice variant (Gβ3-s) with enhanced activity. The T allele of GNB3 was shown recently to be associated with hypertension in unselected German patients (frequency=0.31 versus 0.25 in control). To confirm and extend this finding in a different setting, we performed an association study in Australian white hypertensives. This involved an extensively examined cohort of 110 hypertensives, each of whom were the offspring of 2 hypertensive parents, and 189 normotensives whose parents were both normotensive beyond age 50 years. Genotyping was performed by polymerase chain reaction and digestion with BseDI, which either cut (C allele) or did not cut (T allele) the 268-bp polymerase chain reaction product. T allele frequency in the hypertensive group was 0.43 compared with 0.25 in the normotensive group (χ2=22; P=0.00002; odds ratio=2.3; 95% CI=1.7 to 3.3). The T allele tracked with higher pretreatment blood pressure: diastolic=105±7, 109±16, and 128±28 mm Hg (mean±SD) for CC, CT, and TT, respectively (P=0.001 by 1-way ANOVA). Blood pressures were higher in female hypertensives with a T allele (P=0.006 for systolic and 0.0003 for diastolic by ANOVA) than they were in male hypertensives. In conclusion, the present study of a group with strong family history supports a role for a genetically determined, physiologically active splice variant of the G protein β3 subunit gene in the causation of essential hypertension.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.publisher.placeUSAen_US
dc.relation.ispartofpagefrom1094en_US
dc.relation.ispartofpageto1097en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalHypertensionen_US
dc.relation.ispartofvolume32en_US
dc.titleG-Protein β3 Subunit Gene (GNB3) Variant in Causation of Essential Hypertensionen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, Griffith University Medical Research Collegeen_US
gro.hasfulltextNo Full Text
gro.griffith.authorNyholt, Dale R.
gro.griffith.authorGriffiths, Lyn


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record