Show simple item record

dc.contributor.authorMorris, B.
dc.contributor.authorGriffiths, Lyn
dc.date.accessioned2019-09-17T05:48:17Z
dc.date.available2019-09-17T05:48:17Z
dc.date.issued1998
dc.identifier.issn03051870en_US
dc.identifier.doi10.1111/j.1440-1681.1998.tb02305.x
dc.identifier.urihttp://hdl.handle.net/10072/121996
dc.description.abstract1. Essential hypertension occurs in people with an underlying genetic predisposition who subject themselves to adverse environmental influences. The number of genes involved is unknown, as is the extent to which each contributes to final blood pressure and the severity of the disease. 2. In the past, studies of potential candidate genes have been performed by association (case-control) analysis of unrelated individuals or linkage (pedigree or sibpair) analysis of families. These studies have resulted in several positive findings but, as one may expect, also an enormous number of negative results. 3. In order to uncover the major genetic loci for essential hypertension, it is proposed that scanning the genome systematically in 100-200 affected sibships should prove successful. 4. This involves genotyping sets of hypertensive sibships to determine their complement of several hundred microsatellite polymorphisms. Those that are highly informative, by having a high heterozygosity, are most suitable. Also, the markers need to be spaced sufficiently evenly across the genome so as to ensure adequate coverage. 5. Tests are performed to determine increased segregation of alleles of each marker with hypertension. The analytical tools involve specialized statistical programs that can detect such differences. Non-parametric multipoint analysis is an appropriate approach. 6. In this way, loci for essential hypertension are beginning to emerge.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherBlackwell Publishingen_US
dc.publisher.placeAustraliaen_US
dc.relation.ispartofpagefromS72en_US
dc.relation.ispartofpagetoS78en_US
dc.relation.ispartofissueS1
dc.relation.ispartofjournalClinical and Experimental Pharmacology & Physiologyen_US
dc.relation.ispartofvolume25en_US
dc.titleScanning the genome for essential hypertension loci.en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.hasfulltextNo Full Text
gro.griffith.authorGriffiths, Lyn


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record