Sideroxylonal C, a New Inhibitor of Human Plasminogen Activator Inhibitor Type-1, from the Flowers of Eucalyptus albens
Author(s)
Neve, J
Leone, PD
Carroll, AR
Moni, RW
Paczkowski, NJ
Pierens, G
Bjorquist, P
Deinum, J
Ehnebom, J
Inghardt, T
Guymer, G
Grimshaw, P
Quinn, RJ
Year published
1999
Metadata
Show full item recordAbstract
Sideroxylonal C (3), a new phloroglucinol dimer, was isolated from the flowers of Eucalyptus albens through bioassay-guided fractionation. The structure elucidation was based on 1D and 2D NMR experiments, MS analysis, and comparison with sideroxylonals A (1) and B (2). Sideroxylonal C inhibited human plasminogen activator inhibitor type-1 at 4.7 μM without any significant effect on human tissue plasminogen activator.Sideroxylonal C (3), a new phloroglucinol dimer, was isolated from the flowers of Eucalyptus albens through bioassay-guided fractionation. The structure elucidation was based on 1D and 2D NMR experiments, MS analysis, and comparison with sideroxylonals A (1) and B (2). Sideroxylonal C inhibited human plasminogen activator inhibitor type-1 at 4.7 μM without any significant effect on human tissue plasminogen activator.
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Journal Title
Journal of Natural Products
Volume
62
Issue
2
Subject
Chemical sciences
Biological sciences
Biomedical and clinical sciences
History, heritage and archaeology
Traditional, complementary and integrative medicine