Isolation of Xestosterol Esters of Brominated Acetylenic Fatty Acids from the Marine Sponge Xestospongia testudinaria

Abstract

The CH2Cl2 extract of the marine sponge Xestospongia testudinaria inhibited [3H]DPCPX binding to rat-brain adenosine A1 receptors. Bioassay-guided fractionation led to the isolation of a known brominated acetylenic fatty acid 1 as the active component. Also isolated were two novel sterol esters 2 and 3. All structures were determined on the basis of their spectroscopic data.