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dc.contributor.authorDwyer, D
dc.contributor.authorBrowning, J
dc.contributor.authorWeinstein, S
dc.date.accessioned2020-02-27T06:29:34Z
dc.date.available2020-02-27T06:29:34Z
dc.date.issued1999
dc.identifier.issn1440-2440
dc.identifier.doi10.1016/S1440-2440(99)80006-1
dc.identifier.urihttp://hdl.handle.net/10072/122383
dc.description.abstractThe purpose of this study was to examine whether a single biopsy sample of vastus lateralis could provide an accurate estimate of capillary density (CD) which is indicative of the entire muscle, or whether capillary density is distributed unevenly and varies with muscle depth. Whole muscle cross sections of vastus lateralis were excised post mortem (n=11) for analysis of capillary density at three muscle depths, (superficial, mid and deep regions). Muscle thickness varied widely (17–79mm) across subjects. The distribution of CD throughout the depth of the muscle was homogeneous in 8 subjects, but in 3 subjects it was heterogeneous (p<0.05). In 3 of these subjects there was a significant (p<0.05) effect of sample depth on CD. These data indicate that tissue from a single biopsy will not adequately represent the CD of the entire vastus lateralis in some individuals. Single biopsies from unspecified muscle depth, have routinely been used to estimate CD and fibre type in vastus lateralis. The present study indicates that a more reliable method of analysis would be to use the tissue from two needle biopsies taken at the superficial and deep portions of the muscle from a group of at least 10 subjects. Sampling theory analysis supported this conclusion.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier Science
dc.publisher.placeUK
dc.relation.ispartofpagefrom333
dc.relation.ispartofpageto340
dc.relation.ispartofissue4
dc.relation.ispartofjournalJournal of Science and Medicine in Sport
dc.relation.ispartofvolume2
dc.subject.fieldofresearchSports science and exercise
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode4207
dc.subject.fieldofresearchcode3208
dc.titleThe Reliability of Muscle Biopsies Taken from Vastus Lateralis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.hasfulltextNo Full Text
gro.griffith.authorBrowning, Jay
gro.griffith.authorDwyer, Dan
gro.griffith.authorWeinstein, Stephen R.


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