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dc.contributor.authorTopol, A
dc.contributor.authorEnglish, JA
dc.contributor.authorFlaherty, E
dc.contributor.authorRajarajan, P
dc.contributor.authorHartley, BJ
dc.contributor.authorGupta, S
dc.contributor.authorDesland, F
dc.contributor.authorZhu, S
dc.contributor.authorGoff, T
dc.contributor.authorFriedman, L
dc.contributor.authorRapoport, J
dc.contributor.authorFelsenfeld, D
dc.contributor.authorCagney, G
dc.contributor.authorMackay-Sim, A
dc.contributor.authorSavas, JN
dc.contributor.authorAronow, B
dc.contributor.authorFang, G
dc.contributor.authorZhang, B
dc.contributor.authorCotter, D
dc.contributor.authorBrennand, KJ
dc.date.accessioned2017-10-03T12:30:29Z
dc.date.available2017-10-03T12:30:29Z
dc.date.issued2015
dc.identifier.issn2158-3188
dc.identifier.doi10.1038/tp.2015.118
dc.identifier.urihttp://hdl.handle.net/10072/123421
dc.description.abstractThe genetic and epigenetic factors contributing to risk for schizophrenia (SZ) remain unresolved. Here we demonstrate, for the first time, perturbed global protein translation in human-induced pluripotent stem cell (hiPSC)-derived forebrain neural progenitor cells (NPCs) from four SZ patients relative to six unaffected controls. We report increased total protein levels and protein synthesis, together with two independent sets of quantitative mass spectrometry evidence indicating markedly increased levels of ribosomal and translation initiation and elongation factor proteins, in SZ hiPSC NPCs. We posit that perturbed levels of global protein synthesis in SZ hiPSC NPCs represent a novel post-transcriptional mechanism that might contribute to disease progression.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherNature Publishing Group
dc.relation.ispartofpagefrome662-1
dc.relation.ispartofpagetoe662-12
dc.relation.ispartofjournalTranslational Psychiatry
dc.relation.ispartofvolume5
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchMedical genetics (excl. cancer genetics)
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode320213
dc.titleIncreased abundance of translation machinery in stem cell-derived neural progenitor cells from four schizophrenia patients
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2015. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
gro.hasfulltextFull Text
gro.griffith.authorMackay-Sim, Alan


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