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dc.contributor.authorColson, NJ
dc.contributor.authorLea, RA
dc.contributor.authorQuinlan, S
dc.contributor.authorGriffiths, LR
dc.contributor.editorMelissa Norton
dc.date.accessioned2017-05-03T12:16:04Z
dc.date.available2017-05-03T12:16:04Z
dc.date.issued2006
dc.date.modified2009-01-23T05:39:16Z
dc.identifier.issn1471-2350
dc.identifier.doi10.1186/1471-2350-7-12
dc.identifier.urihttp://hdl.handle.net/10072/12344
dc.description.abstractBackground We have previously reported an association between the estrogen receptor 1 (ESR1) gene exon 8 G594A polymorphism and migraine susceptibility in two independent Australian cohorts. In this paper we report results of analysis of two further single nucleotide polymorphisms (SNPs) in the ESR1 gene in the same study group, the T/C Pvu II SNP in intron 1 and the C325G SNP in exon 4, as well as results of linkage disequilibrium (LD) analysis on these markers. Methods We investigated these variants by case-control association analysis in a cohort of 240 migraineurs and 240 matched controls. The SNPs were genotyped using specific restriction enzyme assays. Results were analysed using contingency table methods incorporating the chi-squared statistic. LD results are presented as D' statistics with associated P values. Results We found no evidence for association of the Pvu II T/C polymorphism and the C325G polymorphism and migraine susceptibility and no evidence for LD between these two SNPs and the previously implicated exon 8 G594A marker. Conclusion We have found no role for the polymorphisms in intron 1 and exon 4 with migraine susceptibility. To further investigate our previously implicated exon 8 marker, we suggest the need for studies with a high density of polymorphisms be undertaken, with particular focus on markers in LD with the exon 8 marker.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent30510 bytes
dc.format.extent293400 bytes
dc.format.mimetypetext/plain
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central Ltd.
dc.publisher.placeUnited Kingdom
dc.publisher.urihttp://www.biomedcentral.com/bmcmedgenet
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto6
dc.relation.ispartofedition2006
dc.relation.ispartofjournalBMC Medical Genetics
dc.relation.ispartofvolume7
dc.rights.retentionY
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3105
dc.subject.fieldofresearchcode3202
dc.titleNo role for estrogen receptor I gene intron I Pvu II and exon 4 C325G polymorphisms in migraine susceptibility
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/2.0
gro.facultyGriffith Health, School of Medical Science
gro.description.notepublicPage numbers are not for citation purposes. Instead, this article has the unique article number of 12.
gro.rights.copyright© 2006 Colson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
gro.date.issued2006
gro.hasfulltextFull Text
gro.griffith.authorColson, Natalie J.


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