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dc.contributor.authorGaman, Amelia Maria
dc.contributor.authorUzoni, Adriana
dc.contributor.authorPopa-Wagner, Aurel
dc.contributor.authorAndrei, Anghel
dc.contributor.authorPetcu, Eugen-Bogdan
dc.date.accessioned2019-04-08T04:22:11Z
dc.date.available2019-04-08T04:22:11Z
dc.date.issued2016
dc.identifier.issn2152-5250
dc.identifier.doi10.14336/AD.2015.1022
dc.identifier.urihttp://hdl.handle.net/10072/123685
dc.description.abstractChemobrain or chemotherapy induced cognitive impairment (CICI) represents a new clinical syndrome characterised by memory, learning and motor function impairment. As numerous patients with cancer are long-term survivors, CICI represent a significant factor which may interfere with their quality of life. However, this entity CICI must be distinguished from other cognitive syndromes and addressed accordingly. At the present time, experimental and clinical research suggests that CICI could be induced by numerous factors including oxidative stress. This type of CNS injury has been previously described in cancer patients treated with common anti-neoplastic drugs such as doxorubicine, carmustine, methotrexate and cyclophosphamide. It seems that all these pharmacological factors promote neuronal death through a final common pathway represented by TNF alpha (tumour necrosis factor). However, as cancer in general is diagnosed more commonly in the aging population, the elderly oncological patient must be treated with great care since aging per se is also impacted by oxidative stress and potentiually by TNF alpha deleterious action on brain parenchyma. In this context, some patients may develop cognitive dysfunction well before the appearance of CICI. In addition, chemotherapy may worsen their cognitive function. Therefore, at the present time, there is an acute need for development of effective therapeutic methods to prevent CICI as well as new methods of early CICI diagnosis.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherBuck Institute for Age Research
dc.relation.ispartofpagefrom307
dc.relation.ispartofpageto317
dc.relation.ispartofissue3
dc.relation.ispartofjournalAging and Disease
dc.relation.ispartofvolume7
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchcode119999
dc.titleThe Role of Oxidative Stress in Etiopathogenesis of Chemotherapy Induced Cognitive Impairment (CICI)-"Chemobrain"
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionPublished
gro.rights.copyright© 2016 Gaman, AM. et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorPetcu, Eugen B.
gro.griffith.authorPopa-Wagner, Aurel


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