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  • MicroRNA in Metabolic Re-Programming and their Role in Tumorigenesis

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    Author(s)
    Tomasetti, Marco
    Amati, Monica
    Santarelli, Lory
    Neuzil, Jiri
    Griffith University Author(s)
    Neuzil, Jiri
    Year published
    2016
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    Abstract
    The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further established their critical role in the initiation, promotion and progression of cancer by creating a tumorigenesis-prone microenvironment, thus orchestrating processes of evasion to apoptosis, angiogenesis and invasion/migration, as well metastasis. Given the involvement of miRNAs in tumour development and their global deregulation, they ...
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    The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further established their critical role in the initiation, promotion and progression of cancer by creating a tumorigenesis-prone microenvironment, thus orchestrating processes of evasion to apoptosis, angiogenesis and invasion/migration, as well metastasis. Given the involvement of miRNAs in tumour development and their global deregulation, they may be perceived as biomarkers in cancer of therapeutic relevance.
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    Journal Title
    International Journal of Molecular Sciences
    Volume
    17
    Issue
    5
    DOI
    https://doi.org/10.3390/ijms17050754
    Copyright Statement
    © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
    Subject
    Oncology and Carcinogenesis not elsewhere classified
    Other Chemical Sciences
    Genetics
    Other Biological Sciences
    Publication URI
    http://hdl.handle.net/10072/123715
    Collection
    • Journal articles

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