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dc.contributor.authorTomasetti, Marco
dc.contributor.authorAmati, Monica
dc.contributor.authorSantarelli, Lory
dc.contributor.authorNeuzil, Jiri
dc.date.accessioned2018-01-22T05:26:15Z
dc.date.available2018-01-22T05:26:15Z
dc.date.issued2016
dc.identifier.issn1422-0067
dc.identifier.doi10.3390/ijms17050754
dc.identifier.urihttp://hdl.handle.net/10072/123715
dc.description.abstractThe process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further established their critical role in the initiation, promotion and progression of cancer by creating a tumorigenesis-prone microenvironment, thus orchestrating processes of evasion to apoptosis, angiogenesis and invasion/migration, as well metastasis. Given the involvement of miRNAs in tumour development and their global deregulation, they may be perceived as biomarkers in cancer of therapeutic relevance.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofpagefrom754-1
dc.relation.ispartofpageto754-19
dc.relation.ispartofissue5
dc.relation.ispartofjournalInternational Journal of Molecular Sciences
dc.relation.ispartofvolume17
dc.subject.fieldofresearchOncology and Carcinogenesis not elsewhere classified
dc.subject.fieldofresearchOther Chemical Sciences
dc.subject.fieldofresearchGenetics
dc.subject.fieldofresearchOther Biological Sciences
dc.subject.fieldofresearchcode111299
dc.subject.fieldofresearchcode0399
dc.subject.fieldofresearchcode0604
dc.subject.fieldofresearchcode0699
dc.titleMicroRNA in Metabolic Re-Programming and their Role in Tumorigenesis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
gro.hasfulltextFull Text
gro.griffith.authorNeuzil, Jiri


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