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dc.contributor.authorZhang, Junen_US
dc.contributor.authorYan, Shengen_US
dc.contributor.authorYuan, Danen_US
dc.contributor.authorAlici, Gurselen_US
dc.contributor.authorNguyen, Nam-Trungen_US
dc.contributor.authorLi, Weihuaen_US
dc.date.accessioned2018-05-03T01:00:27Z
dc.date.available2018-05-03T01:00:27Z
dc.date.issued2016en_US
dc.identifier.doi10.1115/MNHMT2016-6717en_US
dc.identifier.urihttp://hdl.handle.net/10072/123730
dc.description.abstractPlasma is a host of various analytes such as proteins, metabolites, circulating nucleic acids (CNAs), pathogens. The key process of plasma extraction is to eliminate the contamination from blood cells. Conventional methods, such as centrifugation and membrane filtration, are generally lab-intensive, time consuming and even dangerous. In this study, we report an integrated microfluidic device that combines inertial microfluidics and membrane filter. The integrated microfluidic device was evaluated by the diluted (x1/10, x1/20) whole blood, and the quality of the extracted blood plasma was tested. It was found that quality of extracted blood plasma from integrated device was equivalent to that obtained by the centrifugation. This study demonstrates a significant progress towards the practical application of inertial microfluidics with membrane filter for high-throughput and high efficient blood plasma extraction.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherAmerican Society of Mechanical Engineers (ASME)en_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofconferencenameMNHMT 2016en_US
dc.relation.ispartofconferencetitleASME 2016 5th International Conference on Micro/Nanoscale Heat and Mass Transfer, MNHMT 2016en_US
dc.relation.ispartofdatefrom2016-01-04en_US
dc.relation.ispartofdateto2016-01-06en_US
dc.relation.ispartoflocationBiopolis, Singaporeen_US
dc.subject.fieldofresearchMicrotechnologyen_US
dc.subject.fieldofresearchcode091009en_US
dc.titleHigh throughput cell-free extraction of plasma by an integrated microfluidic device combining inertial microfluidics and membraneen_US
dc.typeConference outputen_US
dc.type.descriptionE1 - Conference Publications (HERDC)en_US
dc.type.codeE - Conference Publicationsen_US
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the author[s] for more information.en_US
gro.hasfulltextNo Full Text


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