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dc.contributor.authorHe, Wenni
dc.contributor.authorLiu, Miaomiao
dc.contributor.authorLi, Xiaolin
dc.contributor.authorZhang, Xiaoping
dc.contributor.authorAbdel-Mageed, Wael M
dc.contributor.authorLi, Li
dc.contributor.authorWang, Wenzhao
dc.contributor.authorZhang, Jingyu
dc.contributor.authorHan, Jianying
dc.contributor.authorDai, Huanqin
dc.contributor.authorQuinn, Ronald J
dc.contributor.authorLiu, Hung-wen
dc.contributor.authorLuo, Houwei
dc.contributor.authorZhang, Lixin
dc.contributor.authorLiu, Xueting
dc.date.accessioned2017-11-28T03:36:54Z
dc.date.available2017-11-28T03:36:54Z
dc.date.issued2016
dc.identifier.issn0175-7598
dc.identifier.doi10.1007/s00253-016-7488-6
dc.identifier.urihttp://hdl.handle.net/10072/123733
dc.description.abstractThe biotransformation of tanshinone IIA to a new antibacterial agent tanshisorbicin (1) by the fungus Hypocrea sp. (AS 3.17108) is described. The structure of tanshisorbicin is a hybrid of tanshinone IIA (2) and sorbicillinol (3). The latter is a metabolite produced by Hypocrea sp. The structure of tanshisorbicin was determined using mass spectrometry, NMR spectroscopy, and ECD calculations. The anti-MRSA activity of 1 was found to be significantly higher than that of the parent substrate Tan IIA. Preliminary experiments indicate that tanshisorbicin is formed via a [4+2] cycloaddition reaction that is likely catalyzed by microbial enzyme.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofpagefrom8349
dc.relation.ispartofpageto8357
dc.relation.ispartofissue19
dc.relation.ispartofjournalApplied Microbiology and Biotechnology
dc.relation.ispartofvolume100
dc.subject.fieldofresearchMicrobiology not elsewhere classified
dc.subject.fieldofresearchcode310799
dc.titleFungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorLiu, Miaomiao
gro.griffith.authorHan, Jianying


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