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dc.contributor.authorHuang, Pei
dc.contributor.authorXie, Feng
dc.contributor.authorRen, Biao
dc.contributor.authorWang, Qian
dc.contributor.authorWang, Jian
dc.contributor.authorWang, Qi
dc.contributor.authorAbdel-Mageed, Wael M
dc.contributor.authorLiu, Miaomiao
dc.contributor.authorHan, Jianying
dc.contributor.authorOyeleye, Ayokunmi
dc.contributor.authorShen, Jinzhao
dc.contributor.authorSong, Fuhang
dc.contributor.authorDai, Huanqin
dc.contributor.authorLiu, Xueting
dc.contributor.authorZhang, Lixin
dc.date.accessioned2019-03-31T23:01:53Z
dc.date.available2019-03-31T23:01:53Z
dc.date.issued2016
dc.identifier.issn0175-7598
dc.identifier.doi10.1007/s00253-016-7406-y
dc.identifier.urihttp://hdl.handle.net/10072/123734
dc.description.abstractMicrobes belonging to the genus Verrucosispora possess significant chemical diversity and biological properties. They have attracted the interests of many researchers and are becoming promising resources in the marine natural product research field. A bioassay-guided isolation from the crude extract of Verrucosispora sp. strain MS100047, isolated from sediments collected from the South China Sea, has led to the identification of a new salicylic derivative, glycerol 1-hydroxy-2,5-dimethyl benzoate (1), along with three known compounds, brevianamide F (2), abyssomicin B (3), and proximicin B (4). Compound 1 showed selective activity against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) value of 12.5 μg/mL. Brevianamide F (2), which was isolated from actinomycete for the first time, showed a good anti-BCG activity with a MIC value of 12.5 μg/mL that has not been reported previously in literatures. Proximicin B (4) showed significant anti-MRSA (MIC = 3.125 μg/mL), anti-BCG (MIC = 6.25 μg/mL), and anti-tuberculosis (TB) (MIC = 25 μg/mL) activities. This is the first report on the anti-tubercular activities of proximicins. In addition, Verrucosispora sp. strain MS100047 was found to harbor 18 putative secondary metabolite gene clusters based on genomic sequence analysis. These include the biosynthetic loci encoding polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) consistent with abyssomicins and proximicins, respectively. The biosynthetic pathways of these isolated compounds have been proposed. These results indicate that MS100047 possesses a great potential as a source of active secondary metabolites.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofpagefrom7437
dc.relation.ispartofpageto7447
dc.relation.ispartofissue17
dc.relation.ispartofjournalApplied Microbiology and Biotechnology
dc.relation.ispartofvolume100
dc.subject.fieldofresearchMicrobiology not elsewhere classified
dc.subject.fieldofresearchcode310799
dc.titleAnti-MRSA and anti-TB metabolites from marine-derived Verrucosispora sp. MS100047
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorLiu, Miaomiao


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