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dc.contributor.authorNi, Guoying
dc.contributor.authorWang, Tianfang
dc.contributor.authorYang, Lin
dc.contributor.authorWang, Yuejian
dc.contributor.authorLiu, Xiaosong
dc.contributor.authorWei, Ming Q
dc.date.accessioned2018-09-11T03:51:10Z
dc.date.available2018-09-11T03:51:10Z
dc.date.issued2016
dc.identifier.issn2164-5515
dc.identifier.doi10.1080/21645515.2015.1089008
dc.identifier.urihttp://hdl.handle.net/10072/123750
dc.description.abstractLate stage solid tumors cause significant cancer mortality rates worldwide and effective therapy remains a big challenge. Cancer therapeutic vaccines elicit tumor specific T cells that kill tumor cells yet often fail to result in tumor destruction because of the limited T cell response and the local immune-suppressive environment. Blocking interleukin 10 (IL-10) signaling at the time of therapeutic vaccination elicits much stronger T cell responses than vaccination without IL-10 blocking. Anaerobic oncolytic bacteria target hypoxic regions of the late stage tumor tissues which not only stops tumor growth but also provides a pro-inflammatory environment that may increase the effectiveness of a therapeutic vaccine by recruiting more effector T cells to tumor site. In this review, we argue that combining both bacterial and vaccine therapies may improve the efficiency of late stage cancer management.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherTaylor & Francis
dc.relation.ispartofpagefrom599
dc.relation.ispartofpageto606
dc.relation.ispartofissue3
dc.relation.ispartofjournalHuman Vaccines & Immunotherapeutics
dc.relation.ispartofvolume12
dc.subject.fieldofresearchImmunology
dc.subject.fieldofresearchMedical microbiology
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences
dc.subject.fieldofresearchPharmacology and pharmaceutical sciences not elsewhere classified
dc.subject.fieldofresearchcode3204
dc.subject.fieldofresearchcode3207
dc.subject.fieldofresearchcode3214
dc.subject.fieldofresearchcode321499
dc.titleCombining anaerobic bacterial oncolysis with vaccination that blocks interleukin-10 signaling may achieve better outcomes for late stage cancer management
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.hasfulltextNo Full Text
gro.griffith.authorWei, Ming Q.


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