• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Journal articles
    • View Item
    • Home
    • Griffith Research Online
    • Journal articles
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • The InterLACE study: Design, data harmonization and characteristics across 20 studies on women’s health

    Author(s)
    Mishra, Gita D
    Chung, Hsin-Fang
    Pandeya, Nirmala
    Dobson, Annette J
    Jones, Lee
    Avis, Nancy E
    Crawford, Sybil L
    Gold, Ellen B
    Brown, Daniel
    Sievert, Lynette L
    Brunner, Eric
    Cade, Janet E
    Burley, Victoria J
    Greenwood, Darren C
    Giles, Graham G
    Bruinsma, Fiona
    Goodman, Alissa
    Hayashi, Kunihiko
    Lee, Jung Su
    Mizunuma, Hideki
    Kuh, Diana
    Cooper, Rachel
    Hardy, Rebecca
    Obermeyer, Carla Makhlouf
    Lee, Kathryn A
    Simonsen, Mette Kildevaeld
    Yoshizawa, Toyoko
    Woods, Nancy F
    Mitchell, Ellen S
    Hamer, Mark
    Demakakos, Panayotes
    Sandin, Sven
    Adami, Hans-Olov
    Weiderpass, Elisabete
    Anderson, Debra
    Griffith University Author(s)
    Anderson, Debra J.
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    Objectives The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women’s reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE. Study design InterLACE is an individual-level pooled study of 20 ...
    View more >
    Objectives The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women’s reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE. Study design InterLACE is an individual-level pooled study of 20 observational studies (12 of which are longitudinal) from ten countries. Variables were harmonized across studies to create a new and systematic synthesis of life-course data. Main outcome measures Harmonized data were derived in three domains: 1) socio-demographic and lifestyle factors, 2) female reproductive characteristics, and 3) chronic disease outcomes (cardiovascular disease (CVD) and diabetes). Results InterLACE pooled data from 229,054 mid-aged women. Overall, 76% of the women were Caucasian and 22% Japanese; other ethnicities (of 300 or more participants) included Hispanic/Latin American (0.2%), Chinese (0.2%), Middle Eastern (0.3%), African/black (0.5%), and Other (1.0%). The median age at baseline was 47 years (Inter-quartile range (IQR): 41–53), and that at the last follow-up was 56 years (IQR: 48–64). Regarding reproductive characteristics, half of the women (49.8%) had their first menstruation (menarche) at 12–13 years of age. The distribution of menopausal status and the prevalence of chronic disease varied considerably among studies. At baseline, most women (57%) were pre- or peri-menopausal, 20% reported a natural menopause (range 0.8–55.6%) and the remainder had surgery or were taking hormones. By the end of follow-up, the prevalence rates of CVD and diabetes were 7.2% (range 0.9–24.6%) and 5.1% (range 1.3–13.2%), respectively. Conclusions The scale and heterogeneity of InterLACE data provide an opportunity to strengthen evidence concerning the relationships between reproductive health through life and subsequent risks of chronic disease, including cross-cultural comparisons.
    View less >
    Journal Title
    Maturitas
    Volume
    92
    DOI
    https://doi.org/10.1016/j.maturitas.2016.07.021
    Subject
    Clinical Sciences not elsewhere classified
    Clinical Sciences
    Paediatrics and Reproductive Medicine
    Publication URI
    http://hdl.handle.net/10072/123811
    Collection
    • Journal articles

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander