A model to predict anti-tuberculosis activity: Value proposition for marine microorganisms

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Author(s)
Liu, Miaomiao
Grkovic, Tanja
Zhang, Lixin
Liu, Xueting
Quinn, Ronald J
Griffith University Author(s)
Year published
2016
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Abstract
The development of new antibiotics effective against all strains of tuberculosis (TB) is needed. To evaluate the potential of marine microbe-derived natural products as anti-TB leads, we analyzed and compared the physico-chemical properties of 39 current TB drugs and candidates against 60 confirmed mycobacteria-active natural products. We showed that anti-TB natural products sourced from marine microbes have a large overlap with TB drug-like space. A model to predict potential anti-TB drugs is proposed.
Journal Title
Journal of Antibiotics
Volume
69
DOI
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© 2016 Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, userswill need to obtain permission fromthe license holder to reproduce the material.
Subject
Microbiology
Microbiology not elsewhere classified
Pharmacology and pharmaceutical sciences
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