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  • A model to predict anti-tuberculosis activity: Value proposition for marine microorganisms

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    Author(s)
    Liu, Miaomiao
    Grkovic, Tanja
    Zhang, Lixin
    Liu, Xueting
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Liu, Miaomiao
    Year published
    2016
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    Abstract
    The development of new antibiotics effective against all strains of tuberculosis (TB) is needed. To evaluate the potential of marine microbe-derived natural products as anti-TB leads, we analyzed and compared the physico-chemical properties of 39 current TB drugs and candidates against 60 confirmed mycobacteria-active natural products. We showed that anti-TB natural products sourced from marine microbes have a large overlap with TB drug-like space. A model to predict potential anti-TB drugs is proposed.The development of new antibiotics effective against all strains of tuberculosis (TB) is needed. To evaluate the potential of marine microbe-derived natural products as anti-TB leads, we analyzed and compared the physico-chemical properties of 39 current TB drugs and candidates against 60 confirmed mycobacteria-active natural products. We showed that anti-TB natural products sourced from marine microbes have a large overlap with TB drug-like space. A model to predict potential anti-TB drugs is proposed.
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    Journal Title
    Journal of Antibiotics
    Volume
    69
    DOI
    https://doi.org/10.1038/ja.2016.87
    Copyright Statement
    © 2016 Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, userswill need to obtain permission fromthe license holder to reproduce the material.
    Subject
    Microbiology
    Microbiology not elsewhere classified
    Pharmacology and pharmaceutical sciences
    Publication URI
    http://hdl.handle.net/10072/123857
    Collection
    • Journal articles

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