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  • Turning metabolomics into drug discovery

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    BoufridiPUB1501.pdf (269.5Kb)
    Author(s)
    Boufridi, Asmaa
    Quinn, Ronald J
    Griffith University Author(s)
    Quinn, Ronald J.
    Boufridi, Asmaa
    Year published
    2016
    Metadata
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    Abstract
    Metabolomics is the “omics” that studies the whole metabolome. It has a wide range of applications, inter alia chemotaxonomy, environmental influences, agriculture, etc. Here we review the application of metabolomics in natural product research. The importance of physicochemical properties to drug delivery are discussed in relation to turning metabolomic studies towards drug discovery. We believe that coupling metabolomic studies with standards of known physicochemical properties in order to calibrate the chromatographic columns can be beneficial in identifying compounds of candidate drug quality.Metabolomics is the “omics” that studies the whole metabolome. It has a wide range of applications, inter alia chemotaxonomy, environmental influences, agriculture, etc. Here we review the application of metabolomics in natural product research. The importance of physicochemical properties to drug delivery are discussed in relation to turning metabolomic studies towards drug discovery. We believe that coupling metabolomic studies with standards of known physicochemical properties in order to calibrate the chromatographic columns can be beneficial in identifying compounds of candidate drug quality.
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    Journal Title
    Journal of the Brazilian Chemical Society
    Volume
    27
    Issue
    8
    Publisher URI
    http://jbcs.sbq.org.br/default.asp?ed=241
    DOI
    https://doi.org/10.5935/0103-5053.20160083
    Copyright Statement
    © 2016 Sociedade Brasileira de Química. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Chemical Sciences not elsewhere classified
    Chemical Sciences
    Publication URI
    http://hdl.handle.net/10072/123864
    Collection
    • Journal articles

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