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dc.contributor.authorHall, Susan
dc.contributor.authorMcDermott, Catherine
dc.contributor.authorAnoopkumar-Dukie, Shailendra
dc.contributor.authorMcFarland, Amelia J
dc.contributor.authorForbes, Amanda
dc.contributor.authorPerkins, Anthony V
dc.contributor.authorDavey, Andrew K
dc.contributor.authorChess-Williams, Russ
dc.contributor.authorKiefel, Milton J
dc.contributor.authorArora, Devinder
dc.contributor.authorGrant, Gary D
dc.date.accessioned2018-01-03T04:01:42Z
dc.date.available2018-01-03T04:01:42Z
dc.date.issued2016
dc.identifier.issn2072-6651
dc.identifier.doi10.3390/toxins8080236
dc.identifier.urihttp://hdl.handle.net/10072/123878
dc.description.abstractPyocyanin has recently emerged as an important virulence factor produced by Pseudomonas aeruginosa. The redox-active tricyclic zwitterion has been shown to have a number of potential effects on various organ systems in vitro, including the respiratory, cardiovascular, urological, and central nervous systems. It has been shown that a large number of the effects to these systems are via the formation of reactive oxygen species. The limitations of studies are, to date, focused on the localized effect of the release of pyocyanin (PCN). It has been postulated that, given its chemical properties, PCN is able to readily cross biological membranes, however studies have yet to be undertaken to evaluate this effect. This review highlights the possible manifestations of PCN exposure; however, most studies to date are in vitro. Further high quality in vivo studies are needed to fully assess the physiological manifestations of PCN exposure on the various body systems.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherMDPI AG
dc.relation.ispartofpagefrom236-1
dc.relation.ispartofpageto236-2
dc.relation.ispartofissue8
dc.relation.ispartofjournalToxins
dc.relation.ispartofvolume8
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classified
dc.subject.fieldofresearchBiochemistry and Cell Biology
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences
dc.subject.fieldofresearchcode060199
dc.subject.fieldofresearchcode0601
dc.subject.fieldofresearchcode1115
dc.titleCellular Effects of Pyocyanin, a Secreted Virulence Factor of Pseudomonas aeruginosa
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.facultyGriffith Health, School of Pharmacy
gro.rights.copyright© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
gro.hasfulltextFull Text
gro.griffith.authorPerkins, Anthony V.
gro.griffith.authorKiefel, Milton
gro.griffith.authorHall, Susan
gro.griffith.authorGrant, Gary D.
gro.griffith.authorMcFarland, Amelia J.
gro.griffith.authorAnoopkumar-Dukie, Shailendra
gro.griffith.authorDavey, Andrew
gro.griffith.authorArora, Devinder S.


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