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dc.contributor.authorThorat, Nanasaheb D
dc.contributor.authorBohara, Raghvendra A
dc.contributor.authorTofail, Syed AM
dc.contributor.authorAlothman, Zeid Abdullah
dc.contributor.authorShiddiky, Muhammad JA
dc.contributor.authorHossain, Md Shahriar A
dc.contributor.authorYamauchi, Yusuke
dc.contributor.authorWu, Kevin C-W
dc.date.accessioned2018-03-08T23:25:01Z
dc.date.available2018-03-08T23:25:01Z
dc.date.issued2016
dc.identifier.issn1434-1948
dc.identifier.doi10.1002/ejic.201600706
dc.identifier.urihttp://hdl.handle.net/10072/123894
dc.description.abstractA facile polyol approach for preparing low-Curie-temperature (TC) gadolinium-doped iron oxide nanoparticles (GdIO NPs) for targeted magnetic hyperthermia and chemotherapy coupled with T1–T2 dual-model magnetic resonance (MR) imaging (where T1 and T2 are the longitudinal and transverse relaxation times, respectively) is reported. A small amount of Gd doping decreases the TC of iron oxide down to about 400 K. In the presence of ethanolamine, controlled polyol synthesis leads to the formation of low-TC, highly magnetic (52.87 emu g–1), and size-controlled (ca. 10 nm) GdIO NPs. A further conjugation with folate and a chemotherapeutic drug has been developed, and the whole system is used for in vitro magneto-chemotherapy (magnetic hyperthermia and chemotherapy) for cancer treatment. The synthesized GdIO NPs are stable colloids that are hemocompatible and cytocompatible over a wide concentration range and have a high affinity towards cancer cells. The release of a chemotherapeutic drug from the GdIO NPs significantly affects cancer cell viability, and the T1–T2 dual-model magnetic resonance enhances bioimaging in a breast cancer cell model. We suggest that the chemotherapeutic-drug-conjugated GdIO NPs have great potential for cell targeting and magnetic resonance imaging in cancer magneto-chemotherapy.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto12
dc.relation.ispartofjournalEuropean Journal of Inorganic Chemistry
dc.subject.fieldofresearchInorganic Chemistry not elsewhere classified
dc.subject.fieldofresearchInorganic Chemistry
dc.subject.fieldofresearchOther Chemical Sciences
dc.subject.fieldofresearchcode030299
dc.subject.fieldofresearchcode0302
dc.subject.fieldofresearchcode0399
dc.titleSuperparamagnetic Gadolinium Ferrite Nanoparticles with Controllable Curie Temperature: Cancer Theranostics for MR-Imaging-Guided Magneto-Chemotherapy
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorShiddiky, Muhammad J.


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