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dc.contributor.authorde Oca, Marcela Montes
dc.contributor.authorKumar, Rajiv
dc.contributor.authorRivera, Fabian de Labastida
dc.contributor.authorAmante, Fiona H
dc.contributor.authorSheel, Meru
dc.contributor.authorFaleiro, Rebecca J
dc.contributor.authorBunn, Patrick T
dc.contributor.authorBest, Shannon E
dc.contributor.authorBeattie, Lynette
dc.contributor.authorNg, Susanna S
dc.contributor.authorEdwards, Chelsea L
dc.contributor.authorBoyle, Glen M
dc.contributor.authorPrice, Ric N
dc.contributor.authorAnstey, Nicholas M
dc.contributor.authorLoughland, Jessica R
dc.contributor.authorBurel, Julie
dc.contributor.authorDoolan, Denise L
dc.contributor.authorHaque, Ashraful
dc.contributor.authorMcCarthy, James S
dc.contributor.authorEngwerda, Christian R
dc.date.accessioned2018-02-07T12:00:24Z
dc.date.available2018-02-07T12:00:24Z
dc.date.issued2016
dc.identifier.issn2211-1247
dc.identifier.doi10.1016/j.celrep.2016.09.015
dc.identifier.urihttp://hdl.handle.net/10072/124046
dc.description.abstractThe development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we identify type I interferons (IFNs) as important regulators in developing anti-parasitic immunity in healthy volunteers infected for the first time with Plasmodium falciparum. Type I IFNs suppressed innate immune cell function and parasitic-specific CD4+ T cell IFNγ production, and they promoted the development of parasitic-specific IL-10-producing Th1 (Tr1) cells. Type I IFN-dependent, parasite-specific IL-10 production was also observed in P. falciparum malaria patients in the field following chemoprophylaxis. Parasite-induced IL-10 suppressed inflammatory cytokine production, and IL-10 levels after drug treatment were positively associated with parasite burdens before anti-parasitic drug administration. These findings have important implications for understanding the development of host immune responses following blood-stage P. falciparum infection, and they identify type I IFNs and related signaling pathways as potential targets for therapies or vaccine efficacy improvement.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofpagefrom399
dc.relation.ispartofpageto412
dc.relation.ispartofissue2
dc.relation.ispartofjournalCell Reports
dc.relation.ispartofvolume17
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchBiochemistry and cell biology not elsewhere classified
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode310199
dc.subject.fieldofresearchcode3208
dc.titleType I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2016 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
gro.hasfulltextFull Text
gro.griffith.authorNg, Susanna SS.
gro.griffith.authorBunn, Patrick
gro.griffith.authorEngwerda, Christian R.
gro.griffith.authorBoyle, Glen M.


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