dc.contributor.author | de Oca, Marcela Montes | |
dc.contributor.author | Kumar, Rajiv | |
dc.contributor.author | Rivera, Fabian de Labastida | |
dc.contributor.author | Amante, Fiona H | |
dc.contributor.author | Sheel, Meru | |
dc.contributor.author | Faleiro, Rebecca J | |
dc.contributor.author | Bunn, Patrick T | |
dc.contributor.author | Best, Shannon E | |
dc.contributor.author | Beattie, Lynette | |
dc.contributor.author | Ng, Susanna S | |
dc.contributor.author | Edwards, Chelsea L | |
dc.contributor.author | Boyle, Glen M | |
dc.contributor.author | Price, Ric N | |
dc.contributor.author | Anstey, Nicholas M | |
dc.contributor.author | Loughland, Jessica R | |
dc.contributor.author | Burel, Julie | |
dc.contributor.author | Doolan, Denise L | |
dc.contributor.author | Haque, Ashraful | |
dc.contributor.author | McCarthy, James S | |
dc.contributor.author | Engwerda, Christian R | |
dc.date.accessioned | 2018-02-07T12:00:24Z | |
dc.date.available | 2018-02-07T12:00:24Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2211-1247 | |
dc.identifier.doi | 10.1016/j.celrep.2016.09.015 | |
dc.identifier.uri | http://hdl.handle.net/10072/124046 | |
dc.description.abstract | The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we identify type I interferons (IFNs) as important regulators in developing anti-parasitic immunity in healthy volunteers infected for the first time with Plasmodium falciparum. Type I IFNs suppressed innate immune cell function and parasitic-specific CD4+ T cell IFNγ production, and they promoted the development of parasitic-specific IL-10-producing Th1 (Tr1) cells. Type I IFN-dependent, parasite-specific IL-10 production was also observed in P. falciparum malaria patients in the field following chemoprophylaxis. Parasite-induced IL-10 suppressed inflammatory cytokine production, and IL-10 levels after drug treatment were positively associated with parasite burdens before anti-parasitic drug administration. These findings have important implications for understanding the development of host immune responses following blood-stage P. falciparum infection, and they identify type I IFNs and related signaling pathways as potential targets for therapies or vaccine efficacy improvement. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 399 | |
dc.relation.ispartofpageto | 412 | |
dc.relation.ispartofissue | 2 | |
dc.relation.ispartofjournal | Cell Reports | |
dc.relation.ispartofvolume | 17 | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearch | Biochemistry and cell biology not elsewhere classified | |
dc.subject.fieldofresearch | Medical physiology | |
dc.subject.fieldofresearchcode | 3101 | |
dc.subject.fieldofresearchcode | 310199 | |
dc.subject.fieldofresearchcode | 3208 | |
dc.title | Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © 2016 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Ng, Susanna SS. | |
gro.griffith.author | Bunn, Patrick | |
gro.griffith.author | Engwerda, Christian R. | |
gro.griffith.author | Boyle, Glen M. | |