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dc.contributor.authorMaher, Shaheer
dc.contributor.authorQin, Jie
dc.contributor.authorGulati, Karan
dc.contributor.authorElMekawy, Ahmed
dc.contributor.authorKaur, Gagandeep
dc.contributor.authorLima-Marques, Luis
dc.contributor.authorAtkins, Gerald
dc.contributor.authorFindlay, David M.
dc.contributor.authorEvdokiou, Andreas
dc.contributor.authorLosic, Dusan
dc.date.accessioned2018-02-16T04:32:48Z
dc.date.available2018-02-16T04:32:48Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10072/124221
dc.description.abstractTitanium (Ti) and its alloys have been used for many decades as bone implants, due to their corrosion resistance and appropriate biomechanical properties. Successful implantation may depend on effective osseointegration, requiring biocompatibility of the material and attachment and differentiation of osteoblastic cells. To enhance cellular function in response to the implant surface, micro- and nanoscale topography have been suggested to be critical. In this study, we present engineering of new bone drug-releasing implants, based on 3D-printed Ti-alloy (Ti6Al4V), with a unique dual topography composed of micron-sized spherical particles and vertically aligned titania nanotubes (TNT). The implants were prepared by a combination of two engineering technologies: laser 3D printing of Ti-alloy and electrochemical anodization processes to generate TNT on surface as nano-reservoirs for drug loading and improved interaction with bone cells. To further improve biocompatibility of prepared implants, their modification with hydroxyapatite was performed. The prepared implants were demonstrated for drug delivery applications by loading different therapeutic agents (e.g. antibacterial and anticancer). The results revealed successful drug loading and in-vitro release from TNT-3D-Ti implants. In addition, we studied the compatibility of the prepared implants using fibroblasts. Moreover, antibacterial properties of drug loaded implants were investigated in-vitro. This fabrication approach allows printing of specific implant geometries to meet custom surgical needs, coupled with the ability to release therapeutics locally. This custom printed TNT-3D-Ti implants combined with their localized drugreleasing capabilities have considerable potential to address multiple challenges for current bone implant technology and to improve bone therapy
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherEngineers Australia
dc.publisher.placeAustralia
dc.publisher.urihttps://www.engineersaustralia.org.au/portal/event/chemeca-2016
dc.relation.ispartofconferencenameChemeca 2016
dc.relation.ispartofconferencetitleChemeca 2016: Chemical Engineering - Regeneration, Recovery and Reinvention
dc.relation.ispartofdatefrom2016-09-25
dc.relation.ispartofdateto2016-09-28
dc.relation.ispartoflocationAdelaide, Australia
dc.subject.fieldofresearchMedical Devices
dc.subject.fieldofresearchcode090304
dc.title3D Printed Titanium Implants with Nano-Engineered Surface Titania Nanotubes For Localized Drug Delivery
dc.typeConference output
dc.type.descriptionE1 - Conferences
dc.type.codeE - Conference Publications
gro.hasfulltextNo Full Text
gro.griffith.authorGulati, Karan


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    Contains papers delivered by Griffith authors at national and international conferences.

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