dc.contributor.author | Maher, Shaheer | |
dc.contributor.author | Qin, Jie | |
dc.contributor.author | Gulati, Karan | |
dc.contributor.author | ElMekawy, Ahmed | |
dc.contributor.author | Kaur, Gagandeep | |
dc.contributor.author | Lima-Marques, Luis | |
dc.contributor.author | Atkins, Gerald | |
dc.contributor.author | Findlay, David M. | |
dc.contributor.author | Evdokiou, Andreas | |
dc.contributor.author | Losic, Dusan | |
dc.date.accessioned | 2018-02-16T04:32:48Z | |
dc.date.available | 2018-02-16T04:32:48Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://hdl.handle.net/10072/124221 | |
dc.description.abstract | Titanium (Ti) and its alloys have been used for many decades as bone implants, due to their corrosion
resistance and appropriate biomechanical properties. Successful implantation may depend on effective
osseointegration, requiring biocompatibility of the material and attachment and differentiation of
osteoblastic cells. To enhance cellular function in response to the implant surface, micro- and nanoscale
topography have been suggested to be critical. In this study, we present engineering of new bone
drug-releasing implants, based on 3D-printed Ti-alloy (Ti6Al4V), with a unique dual topography
composed of micron-sized spherical particles and vertically aligned titania nanotubes (TNT). The
implants were prepared by a combination of two engineering technologies: laser 3D printing of Ti-alloy
and electrochemical anodization processes to generate TNT on surface as nano-reservoirs for drug
loading and improved interaction with bone cells. To further improve biocompatibility of prepared
implants, their modification with hydroxyapatite was performed. The prepared implants were
demonstrated for drug delivery applications by loading different therapeutic agents (e.g. antibacterial
and anticancer). The results revealed successful drug loading and in-vitro release from TNT-3D-Ti
implants. In addition, we studied the compatibility of the prepared implants using fibroblasts. Moreover,
antibacterial properties of drug loaded implants were investigated in-vitro. This fabrication approach
allows printing of specific implant geometries to meet custom surgical needs, coupled with the ability to
release therapeutics locally. This custom printed TNT-3D-Ti implants combined with their localized drugreleasing
capabilities have considerable potential to address multiple challenges for current bone
implant technology and to improve bone therapy | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.publisher | Engineers Australia | |
dc.publisher.place | Australia | |
dc.publisher.uri | https://www.engineersaustralia.org.au/portal/event/chemeca-2016 | |
dc.relation.ispartofconferencename | Chemeca 2016 | |
dc.relation.ispartofconferencetitle | Chemeca 2016: Chemical Engineering - Regeneration, Recovery and Reinvention | |
dc.relation.ispartofdatefrom | 2016-09-25 | |
dc.relation.ispartofdateto | 2016-09-28 | |
dc.relation.ispartoflocation | Adelaide, Australia | |
dc.subject.fieldofresearch | Medical Devices | |
dc.subject.fieldofresearchcode | 090304 | |
dc.title | 3D Printed Titanium Implants with Nano-Engineered Surface Titania Nanotubes For Localized Drug Delivery | |
dc.type | Conference output | |
dc.type.description | E1 - Conferences | |
dc.type.code | E - Conference Publications | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Gulati, Karan | |