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dc.contributor.authorSpeicher, DJ
dc.contributor.authorSehu, MM
dc.contributor.authorMollee, P
dc.contributor.authorShen, L
dc.contributor.authorJohnson, NW
dc.contributor.authorFaoagali, JL
dc.date.accessioned2018-11-15T23:25:34Z
dc.date.available2018-11-15T23:25:34Z
dc.date.issued2014
dc.identifier.issn1600-6135
dc.identifier.doi10.1111/ajt.12693
dc.identifier.urihttp://hdl.handle.net/10072/124785
dc.description.abstractWe describe the case of a 59‐year‐old HIV‐negative male who developed multicentric Castleman's disease (MCD) 1 year postliver transplantation due to recrudescence of a pretransplant human herpesvirus‐8 (HHV‐8) infection. He presented with fevers, dry cough, weight loss and drenching night sweats. Routine investigations were all unremarkable. Computerized axial tomography (CT) scans showed splenomegaly and intra‐abdominal lymphadenopathy, confirmed by positron emission tomography. Cervical lymph node biopsies were consistent with MCD. The presence of HHV‐8 was confirmed on immunohistochemistry. Peripheral blood HHV‐8 quantitative polymerase chain reaction (qPCR) monitoring showed a threefold decrease in viremia in the first week of treatment with ganciclovir but had little impact on clinical symptoms. Reducing immunosuppression and switching to rituximab resolved clinical symptoms and produced a negative HHV‐8 qPCR result. Retrospective molecular testing of sera collected pre‐ and immediately posttransplantation confirmed preexisting HHV‐8 in the host. This is the first reported case of an HIV‐negative postliver transplant patient developing MCD that manifested as posttransplant lymphoproliferative disorder due to recrudescence of HHV‐8. We propose (1) the introduction of the term iatrogenic Castleman's disease (CD) for this and similar cases, (2) rituximab should be considered as a treatment option for CD and (3) consideration be given to a change to the World Health Organization classification of CD to incorporate such cases.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing
dc.publisher.placeUnited States
dc.relation.ispartofpagefrom1207
dc.relation.ispartofpageto1213
dc.relation.ispartofjournalAmerican Journal of Transplantation
dc.relation.ispartofvolume14
dc.subject.fieldofresearchOral Medicine and Pathology
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode110505
dc.subject.fieldofresearchcode11
dc.titleSuccessful treatment of iatrogenic multicentric Castleman's disease arising due to recrudescence of HHV-8 in a liver transplant patient
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Dentistry and Oral Health
gro.hasfulltextNo Full Text
gro.griffith.authorSpeicher, David J.
gro.griffith.authorJohnson, Newell W.


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