dc.contributor.author | Tromp, D | |
dc.contributor.author | Christie, DRH | |
dc.date.accessioned | 2019-03-26T00:50:08Z | |
dc.date.available | 2019-03-26T00:50:08Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1433-2981 | |
dc.identifier.doi | 10.1016/j.clon.2015.05.001 | |
dc.identifier.uri | http://hdl.handle.net/10072/124973 | |
dc.description.abstract | Aims:
Inflammatory bowel disease has traditionally been considered a relative contraindication for radiotherapy due to a perceived increased risk of disease exacerbation and bowel toxicity. The aim of this review was to evaluate the current literature regarding rates of radiotherapy-induced acute and late bowel toxicity in patients with inflammatory bowel disease and to compare these data with those of patients without the disease.
Materials and methods:
An Ovid Medline search was conducted to identify original articles pertaining to the review question. Using the PRISMA convention a total of 442 articles screened, resulting 8 articles which were suitable for inclusion in the review.
Results:
In general, the grading of toxicity was scored using either the Radiation Therapy Oncology Group or Common Terminology Criteria for Adverse Events scoring systems. It was found that acute bowel toxicity of ≥ grade 3 occurred in 20% of patients receiving external beam radiotherapy (EBRT) and in 7% of patients receiving brachytherapy. Late bowel toxicity ≥ grade 3 occurred in 15% of EBRT patients and in 5% of patients receiving brachytherapy. Brachytherapy was shown to have similar rates of toxicity and EBRT produced a moderate increase in both acute and late toxicity when compared with individuals without inflammatory bowel disease.
Conclusion:
In view of these results, we suggest that brachytherapy should be considered as a suitable treatment option for treating pelvic malignancy in patients with inflammatory bowel disease, whereas EBRT should be used with caution. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 536 | |
dc.relation.ispartofpageto | 541 | |
dc.relation.ispartofissue | 9 | |
dc.relation.ispartofjournal | Clinical Oncology | |
dc.relation.ispartofvolume | 27 | |
dc.subject.fieldofresearch | Oncology and carcinogenesis | |
dc.subject.fieldofresearch | Oncology and carcinogenesis not elsewhere classified | |
dc.subject.fieldofresearchcode | 3211 | |
dc.subject.fieldofresearchcode | 321199 | |
dc.title | Acute and Late Bowel Toxicity in Radiotherapy Patients with Inflammatory Bowel Disease: A Systematic Review | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Health, School of Medicine | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Tromp, Dirk | |