A recent bottleneck of Y chromosome diversity coincides with a global change in culture

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Author(s)
Karmin, Monika
Saag, Lauri
Vicente, Mario
Sayres, Melissa A Wilson
Jarve, Mari
Talas, Ulvi Gerst
Rootsi, Siiri
Ilumaee, Anne-Mai
Maegi, Reedik
Mitt, Mario
Pagani, Luca
Puurand, Tarmo
Faltyskova, Zuzana
Clemente, Florian
Cardona, Alexia
Metspalu, Ene
Sahakyan, Hovhannes
Yunusbayev, Bayazit
Hudjashov, Georgi
DeGiorgio, Michael
Loogvaeli, Eva-Liis
Eichstaedt, Christina
Eelmets, Mikk
Chaubey, Gyaneshwer
Tambets, Kristiina
Litvinov, Sergei
Mormina, Maru
Xue, Yali
Ayub, Qasim
Zoraqi, Grigor
Korneliussen, Thorfinn Sand
Akhatova, Farida
Lachance, Joseph
Tishkoff, Sarah
Momynaliev, Kuvat
Ricaut, Francois-Xavier
Kusuma, Pradiptajati
Razafindrazaka, Harilanto
Pierron, Denis
Cox, Murray P
Nurun, Gazi
Sultana, Nahar
Willerslev, Rane
Muller, Craig
Westaway, Michael
Lambert, David
Skaro, Vedrana
Kovacevic, Lejla
Turdikulova, Shahlo
Dalimova, Dilbar
Khusainova, Rita
Trofimova, Natalya
Akhmetova, Vita
Khidiyatova, Irina
Lichman, Daria V
Isakova, Jainagul
Pocheshkhova, Elvira
Sabitov, Zhaxylyk
Barashkov, Nikolay A
Nymadawa, Pagbajabyn
Mihailov, Evelin
Seng, Joseph Wee Tien
Evseeva, Irina
Migliano, Andrea Bamberg
Abdullah, Syafiq
Andriadze, George
Primorac, Dragan
Atramentova, Lubov
Utevska, Olga
Yepiskoposyan, Levon
Marjanovic, Damir
Kushniarevich, Alena
Behar, Doron M
Gilissen, Christian
Vissers, Lisenka
Veltman, Joris A
Balanovska, Elena
Derenko, Miroslava
Malyarchuk, Boris
Metspalu, Andres
Fedorova, Sardana
Eriksson, Anders
Manica, Andrea
Mendez, Fernando L
Karafet, Tatiana M
Veeramah, Krishna R
Bradman, Neil
Hammer, Michael F
Osipova, Ludmila P
Balanovsky, Oleg
Khusnutdinova, Elza K
Johnsen, Knut
Remm, Maido
Thomas, Mark G
Tyler-Smith, Chris
Underhill, Peter A
Willerslev, Eske
Nielsen, Rasmus
Metspalu, Mait
Villems, Richard
Kivisild, Toomas
Griffith University Author(s)
Year published
2015
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Show full item recordAbstract
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. ...
View more >It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
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View more >It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
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Journal Title
Genome Research
Volume
25
Issue
4
Copyright Statement
© 2015 Karmin et al. This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/bync/4.0/.
Subject
Biological sciences
Genetics not elsewhere classified
Biomedical and clinical sciences