Elicitation of secondary metabolism in actinomycetes

Abdelmohsen, Usama Ramadan; Grkovic, Tanja; Balasubramanian, Srikkanth; Kamel, Mohamed Salah; Quinn, Ronald; Hentschel, Ute

doi:10.1016/j.biotechadv.2015.06.003

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Author

Abdelmohsen, Usama Ramadan

Grkovic, Tanja

Balasubramanian, Srikkanth

Kamel, Mohamed Salah

Quinn, Ronald

Hentschel, Ute

Year published

2015

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Abstract

Genomic sequence data have revealed the presence of a large fraction of putatively silent biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary metabolites, which are not detected under standard fermentation conditions. This review focuses on the effects of biological (co-cultivation), chemical, as well as molecular elicitation on secondary metabolism in actinomycetes. Our review covers the literature until June 2014 and exemplifies the diversity of natural products that have been recovered by such approaches from the phylum Actinobacteria.

Journal Title

Biotechnology Advances

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DOI

https://doi.org/10.1016/j.biotechadv.2015.06.003

Copyright Statement

Copyright 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.

Subject

Biological Sciences not elsewhere classified

Publication URI

http://hdl.handle.net/10072/125137

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