Elicitation of secondary metabolism in actinomycetes

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Author(s)
Abdelmohsen, Usama Ramadan
Grkovic, Tanja
Balasubramanian, Srikkanth
Kamel, Mohamed Salah
Quinn, Ronald J
Hentschel, Ute
Griffith University Author(s)
Year published
2015
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Abstract
Genomic sequence data have revealed the presence of a large fraction of putatively silent biosynthetic gene clusters in the genomes of actinomycetes that encode for secondary metabolites, which are not detected under standard fermentation conditions. This review focuses on the effects of biological (co-cultivation), chemical, as well as molecular elicitation on secondary metabolism in actinomycetes. Our review covers the literature until June 2014 and exemplifies the diversity of natural products that have been recovered by such approaches from the phylum Actinobacteria.
Journal Title
Biotechnology Advances
Volume
33
Issue
6
DOI
Copyright Statement
© 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
Subject
Biological Sciences not elsewhere classified
Biological Sciences
Engineering
Technology
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