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  • Circulating cell-free tumour DNA in the management of cancer

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    Author(s)
    Francis, G
    Stein, S
    Griffith University Author(s)
    Francis, Glenn D.
    Year published
    2015
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    Abstract
    With the development of new sensitive molecular techniques, circulating cell-free tumour DNA containing mutations can be identified in the plasma of cancer patients. The applications of this technology may result in significant changes to the care and management of cancer patients. Whilst, currently, these “liquid biopsies” are used to supplement the histological diagnosis of cancer and metastatic disease, in the future these assays may replace the need for invasive procedures. Applications include the monitoring of tumour burden, the monitoring of minimal residual disease, monitoring of tumour heterogeneity, monitoring of ...
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    With the development of new sensitive molecular techniques, circulating cell-free tumour DNA containing mutations can be identified in the plasma of cancer patients. The applications of this technology may result in significant changes to the care and management of cancer patients. Whilst, currently, these “liquid biopsies” are used to supplement the histological diagnosis of cancer and metastatic disease, in the future these assays may replace the need for invasive procedures. Applications include the monitoring of tumour burden, the monitoring of minimal residual disease, monitoring of tumour heterogeneity, monitoring of molecular resistance and early diagnosis of tumours and metastatic disease.
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    Journal Title
    International Journal of Molecular Sciences
    Volume
    16
    Issue
    6
    DOI
    https://doi.org/10.3390/ijms160614122
    Copyright Statement
    © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
    Subject
    Other chemical sciences
    Genetics
    Genetics not elsewhere classified
    Other biological sciences
    Publication URI
    http://hdl.handle.net/10072/125159
    Collection
    • Journal articles

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