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  • Strategic development of the conserved region of the M protein and other candidates as vaccines to prevent infection with group A streptococci

    Author(s)
    Good, Michael F
    Pandey, Manisha
    Batzloff, Michael R
    Tyrrell, Gregory J
    Griffith University Author(s)
    Pandey, Manisha
    Good, Michael F.
    Year published
    2015
    Metadata
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    Abstract
    Group A streptococcal (Streptococcus pyogenes) diseases remain a major public health problem in developing countries as well as in the indigenous populations of developed countries. In view of the large number of Group A streptococcal infections and the potential for sequelae such as rheumatic heart disease, control strategies including the development of an anti-streptococcal vaccine that is able to prevent infection and colonization is important. In this article, we discuss the epidemiology and strain variability of Group A streptococcus and how this is rendering vaccine development more challenging. We discuss vaccine ...
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    Group A streptococcal (Streptococcus pyogenes) diseases remain a major public health problem in developing countries as well as in the indigenous populations of developed countries. In view of the large number of Group A streptococcal infections and the potential for sequelae such as rheumatic heart disease, control strategies including the development of an anti-streptococcal vaccine that is able to prevent infection and colonization is important. In this article, we discuss the epidemiology and strain variability of Group A streptococcus and how this is rendering vaccine development more challenging. We discuss vaccine strategies with a focus on the conserved region of the M protein and present a viewpoint for the impediments and the way forward.
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    Journal Title
    Expert Review of Vaccines
    Volume
    14
    Issue
    11
    DOI
    https://doi.org/10.1586/14760584.2015.1081817
    Subject
    Clinical sciences
    Clinical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/125189
    Collection
    • Journal articles

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