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  • Fc receptors in antibody-dependent enhancement of viral infections

    Author(s)
    Taylor, Adam
    Foo, Suan-Sin
    Bruzzone, Roberto
    Vu Dinh, Luan
    King, Nicholas JC
    Mahalingam, Suresh
    Griffith University Author(s)
    Mahalingam, Suresh
    Foo, Jolin
    Taylor, Adam
    Year published
    2015
    Metadata
    Show full item record
    Abstract
    Sensitization of the humoral immune response to invading viruses and production of antiviral antibodies forms part of the host antiviral repertoire. Paradoxically, for a number of viral pathogens, under certain conditions, antibodies provide an attractive means of enhanced virus entry and replication in a number of cell types. Known as antibody-dependent enhancement (ADE) of infection, the phenomenon occurs when virus-antibody immunocomplexes interact with cells bearing complement or Fc receptors, promoting internalization of the virus and increasing infection. Frequently associated with exacerbation of viral disease, ADE ...
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    Sensitization of the humoral immune response to invading viruses and production of antiviral antibodies forms part of the host antiviral repertoire. Paradoxically, for a number of viral pathogens, under certain conditions, antibodies provide an attractive means of enhanced virus entry and replication in a number of cell types. Known as antibody-dependent enhancement (ADE) of infection, the phenomenon occurs when virus-antibody immunocomplexes interact with cells bearing complement or Fc receptors, promoting internalization of the virus and increasing infection. Frequently associated with exacerbation of viral disease, ADE of infection presents a major obstacle to the prevention of viral disease by vaccination and is thought to be partly responsible for the adverse effects of novel antiviral therapeutics such as intravenous immunoglobulins. There is a growing body of work examining the intracellular signaling pathways and epitopes responsible for mediating ADE, with a view to aiding rational design of antiviral strategies. With in vitro studies also confirming ADE as a feature of infection for a growing number of viruses, challenges remain in understanding the multilayered molecular mechanisms of ADE and its effect on viral pathogenesis.
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    Journal Title
    Immunological Reviews
    Volume
    268
    Issue
    1
    DOI
    https://doi.org/10.1111/imr.12367
    Subject
    Immunology not elsewhere classified
    Immunology
    Publication URI
    http://hdl.handle.net/10072/125190
    Collection
    • Journal articles

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