dc.contributor.author | Good, Michael F | |
dc.contributor.author | Hawkes, Michael T | |
dc.contributor.author | Yanow, Stephanie K | |
dc.date.accessioned | 2018-03-06T22:54:11Z | |
dc.date.available | 2018-03-06T22:54:11Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 1471-4922 | |
dc.identifier.doi | 10.1016/j.pt.2015.06.008 | |
dc.identifier.uri | http://hdl.handle.net/10072/125202 | |
dc.description.abstract | Malaria vaccine development is hampered by the lack of small animal models that recapitulate human immune responses to Plasmodium falciparum. We review the burgeoning literature on humanized mice for P. falciparum infection, including challenges in engraftment of human immune cells, hepatocytes, and erythrocytes. Recent advances in immune-compromised mouse models and stem cell technology have already enabled proof of concept that the entire parasite life cycle can be sustained in a murine model and that adaptive human immune responses to several parasite stages can be measured. Nonetheless, optimization is needed to achieve a reproducible and relevant murine model for malaria vaccine development. This review is focused on the complexities of T cell development in a mouse humanized with both a lymphoid system and hepatocytes. An understanding of this will facilitate the use of humanized mice in the development of liver-stage vaccines. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofpagefrom | 583 | |
dc.relation.ispartofpageto | 594 | |
dc.relation.ispartofissue | 11 | |
dc.relation.ispartofjournal | Trends in Parasitology | |
dc.relation.ispartofvolume | 31 | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Agricultural, veterinary and food sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 30 | |
dc.subject.fieldofresearchcode | 32 | |
dc.title | Humanized Mouse Models to Study Cell-Mediated Immune Responses to Liver-Stage Malaria Vaccines | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
dcterms.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.description.version | Accepted Manuscript (AM) | |
gro.faculty | Office of the Snr Dep Vice Chancellor, Institute for Glycomics | |
gro.rights.copyright | © 2015 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Good, Michael F. | |