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  • Protocol for assessing maternal, environmental and epigenetic risk factors for dental caries in children

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    FernandoPUB810.pdf (487.6Kb)
    Author(s)
    Fernando, Surani
    Speicher, David J
    Bakr, Mahmoud M
    Benton, Miles C
    Lea, Rodney A
    Scuffham, Paul A
    Mihala, Gabor
    Johnson, Newell W
    Griffith University Author(s)
    Speicher, David J.
    Johnson, Newell W.
    Scuffham, Paul A.
    Mihala, Gabor
    Bakr, Mahmoud
    Fernando, Surani
    Benton, Miles
    Year published
    2015
    Metadata
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    Abstract
    Background: Expenditure on dental and oral health services in Australia is $3.4 billion AUD annually. This is the sixth highest health cost and accounts for 7 % of total national health expenditure. Approximately 49 % of Australian children aged 6 years have caries experience in their deciduous teeth and this is rising. The aetiology of dental caries involves a complex interplay of individual, behavioural, social, economic, political and environmental conditions, and there is increasing interest in genetic predisposition and epigenetic modification. Methods: The Oral Health Sub-study; a cross sectional study of a birth ...
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    Background: Expenditure on dental and oral health services in Australia is $3.4 billion AUD annually. This is the sixth highest health cost and accounts for 7 % of total national health expenditure. Approximately 49 % of Australian children aged 6 years have caries experience in their deciduous teeth and this is rising. The aetiology of dental caries involves a complex interplay of individual, behavioural, social, economic, political and environmental conditions, and there is increasing interest in genetic predisposition and epigenetic modification. Methods: The Oral Health Sub-study; a cross sectional study of a birth cohort began in November 2012 by examining mothers and their children who were six years old by the time of initiation of the study, which is ongoing. Data from detailed questionnaires of families from birth onwards and data on mothers’ knowledge, attitudes and practices towards oral health collected at the time of clinical examination are used. Subjects’ height, weight and mid-waist circumference are taken and Body Mass Index (BMI) computed, using an electronic Bio-Impedance balance. Dental caries experience is scored using the International Caries Detection and Assessment System (ICDAS). Saliva is collected for physiological measures. Salivary Deoxyribose Nucleic Acid (DNA) is extracted for genetic studies including epigenetics using the SeqCap Epi Enrichment Kit. Targets of interest are being confirmed by pyrosequencing to identify potential epigenetic markers of caries risk. Discussion: This study will examine a wide range of potential determinants for childhood dental caries and evaluate inter-relationships amongst them. The findings will provide an evidence base to plan and implement improved preventive strategies.
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    Journal Title
    BMC Oral Health
    Volume
    15
    DOI
    https://doi.org/10.1186/s12903-015-0143-2
    Copyright Statement
    © Fernando et al. 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
    Subject
    Paedodontics
    Dentistry
    Publication URI
    http://hdl.handle.net/10072/125229
    Collection
    • Journal articles

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