Show simple item record

dc.contributor.authorFernando, Surani
dc.contributor.authorSpeicher, David J
dc.contributor.authorBakr, Mahmoud M
dc.contributor.authorBenton, Miles C
dc.contributor.authorLea, Rodney A
dc.contributor.authorScuffham, Paul A
dc.contributor.authorMihala, Gabor
dc.contributor.authorJohnson, Newell W
dc.date.accessioned2018-03-22T23:07:06Z
dc.date.available2018-03-22T23:07:06Z
dc.date.issued2015
dc.identifier.issn1472-6831
dc.identifier.doi10.1186/s12903-015-0143-2
dc.identifier.urihttp://hdl.handle.net/10072/125229
dc.description.abstractBackground: Expenditure on dental and oral health services in Australia is $3.4 billion AUD annually. This is the sixth highest health cost and accounts for 7 % of total national health expenditure. Approximately 49 % of Australian children aged 6 years have caries experience in their deciduous teeth and this is rising. The aetiology of dental caries involves a complex interplay of individual, behavioural, social, economic, political and environmental conditions, and there is increasing interest in genetic predisposition and epigenetic modification. Methods: The Oral Health Sub-study; a cross sectional study of a birth cohort began in November 2012 by examining mothers and their children who were six years old by the time of initiation of the study, which is ongoing. Data from detailed questionnaires of families from birth onwards and data on mothers’ knowledge, attitudes and practices towards oral health collected at the time of clinical examination are used. Subjects’ height, weight and mid-waist circumference are taken and Body Mass Index (BMI) computed, using an electronic Bio-Impedance balance. Dental caries experience is scored using the International Caries Detection and Assessment System (ICDAS). Saliva is collected for physiological measures. Salivary Deoxyribose Nucleic Acid (DNA) is extracted for genetic studies including epigenetics using the SeqCap Epi Enrichment Kit. Targets of interest are being confirmed by pyrosequencing to identify potential epigenetic markers of caries risk. Discussion: This study will examine a wide range of potential determinants for childhood dental caries and evaluate inter-relationships amongst them. The findings will provide an evidence base to plan and implement improved preventive strategies.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofpagefrom167-1
dc.relation.ispartofpageto167-8
dc.relation.ispartofjournalBMC Oral Health
dc.relation.ispartofvolume15
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchPaedodontics
dc.subject.fieldofresearchcode3203
dc.subject.fieldofresearchcode320309
dc.titleProtocol for assessing maternal, environmental and epigenetic risk factors for dental caries in children
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© Fernando et al. 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
gro.hasfulltextFull Text
gro.griffith.authorJohnson, Newell W.
gro.griffith.authorScuffham, Paul A.
gro.griffith.authorBakr, Mahmoud


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record