dc.contributor.author | Atkinson, Caroline J | |
dc.contributor.author | Zhang, Kai | |
dc.contributor.author | Munn, Alan L | |
dc.contributor.author | Wiegmans, Adrian | |
dc.contributor.author | Wei, Ming Q | |
dc.date.accessioned | 2017-12-13T05:09:54Z | |
dc.date.available | 2017-12-13T05:09:54Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1933-6896 | |
dc.identifier.doi | 10.1080/19336896.2015.1110293 | |
dc.identifier.uri | http://hdl.handle.net/10072/125431 | |
dc.description.abstract | Prions are infectious proteins and over the past few decades, some prions have become renowned for their causative role in several neurodegenerative diseases in animals and humans. Since their discovery, the mechanisms and mode of transmission and molecular structure of prions have begun to be established. There is, however, still much to be elucidated about prion diseases, including the development of potential therapeutic strategies for treatment. The significance of prion disease is discussed here, including the categories of human and animal prion diseases, disease transmission, disease progression and the development of symptoms and potential future strategies for treatment. Furthermore, the structure and function of the normal cellular prion protein (PrPC) and its importance in not only in prion disease development, but also in diseases such as cancer and Alzheimer's disease will also be discussed. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | Taylor & Francis | |
dc.relation.ispartofpagefrom | 1 | |
dc.relation.ispartofpageto | 8 | |
dc.relation.ispartofjournal | Prion | |
dc.subject.fieldofresearch | Biochemistry and cell biology | |
dc.subject.fieldofresearch | Gene and molecular therapy | |
dc.subject.fieldofresearchcode | 3101 | |
dc.subject.fieldofresearchcode | 320601 | |
dc.title | Prion Protein Scrapie and the Normal Cellular Prion Protein | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.faculty | Griffith Health, School of Medical Science | |
gro.description.notepublic | This publication has been entered into Griffith Research Online as an Advanced Online Version. | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Munn, Alan L. | |
gro.griffith.author | Wei, Ming Q. | |