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dc.contributor.authorKhera, Alisha
dc.contributor.authorDong, Lan-feng
dc.contributor.authorHolland, Olivia
dc.contributor.authorVanderlelie, Jessica
dc.contributor.authorPasdar, Elham A
dc.contributor.authorNeuzil, Jiri
dc.contributor.authorPerkins, Anthony V
dc.date.accessioned2018-01-24T00:02:50Z
dc.date.available2018-01-24T00:02:50Z
dc.date.issued2015
dc.identifier.issn0143-4004
dc.identifier.doi10.1016/j.placenta.2015.06.010
dc.identifier.urihttp://hdl.handle.net/10072/127913
dc.description.abstractIntroduction: Placental oxidative stress has been implicated in pregnancy complications and previous work has shown that selenium can protect trophoblast mitochondria from oxidative stress. This report examines mitochondrial function and content in trophoblasts supplemented with selenium. Methods: Swan-71, JEG-3 and BeWo cells and placental tissue were incubated with sodium selenite or selenomethionine. Mitochondrial function was examined in a respirometer. Mitochondrial content was determined using RT-PCR. The levels of the mitochondrial biogenesis markers selenoprotein H, PGC-1a and NRF-1 was examined by western blotting. Results: Mitochondrial respiration was significantly enhanced post selenium supplementation in cells and tissues. Selenium supplementation increased mitochondrial content and up-regulated mitochondrial biogenesis mediators in cells. Discussion: These results emphasise the importance of selenium in mitochondrial regeneration in trophoblasts.
dc.description.peerreviewedYes
dc.languageEnglish
dc.language.isoeng
dc.publisherElsevier
dc.publisher.placeUnited Kingdom
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto7
dc.relation.ispartofjournalPlacenta
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchCell metabolism
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode310103
dc.subject.fieldofresearchcode3202
dc.titleSelenium supplementation induces mitochondrial biogenesis in trophoblasts
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.facultyGriffith Health, School of Medical Science
gro.description.notepublicThis publication has been entered into Griffith Research Online as an Advanced Online Version.
gro.hasfulltextNo Full Text
gro.griffith.authorNeuzil, Jiri
gro.griffith.authorHolland, Olivia J.


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