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dc.contributor.authorMcCarthy, Alexandra L
dc.contributor.authorShaban, Ramon Z
dc.contributor.authorGillespie, Kerri
dc.contributor.authorVick, Joanne
dc.date.accessioned2017-11-27T12:00:53Z
dc.date.available2017-11-27T12:00:53Z
dc.date.issued2014
dc.identifier.issn0941-4355
dc.identifier.doi10.1007/s00520-013-2095-x
dc.identifier.urihttp://hdl.handle.net/10072/128212
dc.description.abstractPurpose This study investigated the efficacy and safety of cryotherapy, in the form of frozen gel gloves, in relation to docetaxel-induced hand and fingernail toxicities. Patients and methods After piloting with 21 patients, a consecutive series sample of patients (n=53) prescribed docetaxel every 3 weeks, for a minimum of three cycles, was enrolled in this randomised control trial. Participants acted as their own control, with the frozen gel glove worn on one randomised hand for 15 min prior to infusion, for the duration of the infusion, and for 15 min of after completion of treatment. Hand and nail toxicities were evaluated by two blinded assessors according to CTCAE.v4 criteria. To assess the potential for cross-infection of multi-use gloves, microbial culture and sensitivity swabs were taken of each glove at every tenth use. Results Of the 53 participants enrolled in the main study, 21 provided evaluable data. There was a 60%withdrawal rate due to patient discomfort with the intervention. Themean incidence and severity of toxicities in all evaluable cycles in control and intervention hands respectively were erythroderma grade 1 (5/5 %), nail discolouration grade 1 (81/67 %), nail loss grade 1 (19/19 %) and nail ridging grade 1 (57/57 %). No significant differences were determined between hand conditions in terms of time to event, nor in terms of toxicity in gloved and nongloved hands. Conclusion While cryotherapy in the form of frozen gloves for the cutaneous toxicities associated with docetaxel is safe, its limited efficacy, patient discomfort and some logistical issues preclude its use in our clinical setting.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherSpringer
dc.publisher.placeGermany
dc.relation.ispartofpagefrom1375
dc.relation.ispartofpageto1383
dc.relation.ispartofissue5
dc.relation.ispartofjournalSupportive Care in Cancer
dc.relation.ispartofvolume22
dc.subject.fieldofresearchChemotherapy
dc.subject.fieldofresearchNursing not elsewhere classified
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchPsychology and Cognitive Sciences
dc.subject.fieldofresearchcode111205
dc.subject.fieldofresearchcode111099
dc.subject.fieldofresearchcode11
dc.subject.fieldofresearchcode17
dc.titleCryotherapy for docetaxel-induced hand and nail toxicity: randomised control trial
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.hasfulltextNo Full Text
gro.griffith.authorShaban, Ramon Z.
gro.griffith.authorMcCarthy, Alexandra L.


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