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dc.contributor.authorFoxwell, A Ruth
dc.contributor.authorCripps, Allan W
dc.contributor.authorDear, Keith BG
dc.date.accessioned2019-03-15T00:26:40Z
dc.date.available2019-03-15T00:26:40Z
dc.date.issued2010
dc.identifier.issn1469-493X
dc.identifier.doi10.1002/14651858.CD001958.pub3
dc.identifier.urihttp://hdl.handle.net/10072/136583
dc.description.abstractBackground: Acute bronchitis leading to ongoing exacerbations is a serious condition predisposed to by viruses or bacteria. It can be fatal. Antibiotic therapy has not been particularly useful in clearing bacteria such as nontypeable Haemophilus inuenzae (NTHi) because they colonise the upper respiratory tract. An oral NTHi vaccine has been developed to protect against recurrent acute episodes in chronic bronchitis. Objectives: To assess the effects of an oral whole cell nontypeable Haemophilus infuenzae (NTHi) vaccine in protecting against recurrent acute episodes in chronic bronchitis. Search strategy: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (issue 1, 2003); MEDLINE (1966 to 2003); EMBASE (1990 - 2003); Extramed (1994 to 2003); ISI Current Contents (1993 to 2003); Carl Uncover (1988 to 2003) and contacted investigators of the studies. Selection criteria: Randomised trials comparing the effects of an oral monobacterial NTHi vaccine on patients with recurrent acute exacerbations of chronic bronchitis were included when there was overt matching of the vaccine and placebo groups on clinical grounds. Data collection and analysis: Three reviewers extracted data and assessed trial quality independently from original records and publications for incidence and severity of bronchitis episodes and carriage rate of nontypeable Haemophilus infuenzae measured in the upper respiratory tract every three months following vaccination. Main results: Six trials were included in the study with a total of 440 participants. Oral vaccination using a monobacterial whole cell killed nontypeable Haemophilus infuenzae significantly reduced the incidence of bronchitic episodes at three months after vaccination (Poisson rate ratio 0.666; 95% con dence interval [CI] 0.500, 0.887; p = 0.005) and perhaps at six months after vaccination (Poisson rate ratio 0.831; 95% CI 0.669, 1.031; p = 0.093). The effect had disappeared by nine months. The severity of exacerbations in the treatment group, as measured by requirement to prescribe antibiotics, was likewise reduced by 58% at three months (Peto odds ratio = 0.42; 95% CI 0.16, - 1.13), and by 65% at six months (Peto odds ratio = 0.35; 95% CI 0.16, - 0.75). Authors' conclusions Vaccination, in the autumn, of patients with recurrent acute exacerbations of chronic bronchitis reduced the number and severity of exacerbations over the winter months. A large clinical trial to assess longer term prognosis is needed.
dc.languageEnglish
dc.publisherJohn Wiley & Sons Ltd
dc.relation.ispartofpagefrom1
dc.relation.ispartofpageto11
dc.relation.ispartofissue3
dc.subject.fieldofresearchImmunology not elsewhere classified
dc.subject.fieldofresearchMedical Microbiology not elsewhere classified
dc.subject.fieldofresearchMedical and Health Sciences
dc.subject.fieldofresearchcode110799
dc.subject.fieldofresearchcode110899
dc.subject.fieldofresearchcode11
dc.titleHaemophilus influenzae oral whole cell vaccination for preventing acute exacerbations of chronic bronchitis (Review).
dc.typeReport
dc.type.descriptionU2 - Reviews/Reports
dc.type.codeD - Reviews/Reports
dc.description.versionPublished
gro.description.notepublicThis paper has been Withdrawn from the publishers site. Please see publisher's website for details. The attached file is for the previous version (2006) of this paper
gro.rights.copyright© 2006 The Cochrane Collaboration. Published by JohnWiley & Sons, Ltd. This review is published as a Cochrane Review in the Cochrane Database of Systematic Reviews 2006, 4. Cochrane Reviews are regularly updated as new evidence emerges and in response to comments and criticisms, and the Cochrane Database of Systematic Reviews should be consulted for the most recent version of the Review.
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gro.griffith.authorCripps, Allan W.


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