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  • Ontogeny of mucosal immunity and aging

    Author(s)
    Gleeson, M
    Cripps, AW
    Griffith University Author(s)
    Cripps, Allan W.
    Year published
    2015
    Metadata
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    Abstract
    The mucosal immune system begins development in utero at as early as 40 days gestation, and by the time of birth all components of the system are in place and have the potential to effectively respond to antigenic challenge. In early childhood development is influenced by many factors such as maternal stress, feeding practices, the mucosal microbiome, vaccination, nutritional status, infection, and the host of environmental antigens encountered. Mucosal immune function reaches that observed in adults around the age of five to seven years. There is some evidence to suggest that developmental profiles of mucosal immunity in ...
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    The mucosal immune system begins development in utero at as early as 40 days gestation, and by the time of birth all components of the system are in place and have the potential to effectively respond to antigenic challenge. In early childhood development is influenced by many factors such as maternal stress, feeding practices, the mucosal microbiome, vaccination, nutritional status, infection, and the host of environmental antigens encountered. Mucosal immune function reaches that observed in adults around the age of five to seven years. There is some evidence to suggest that developmental profiles of mucosal immunity in childhood may be related to disease susceptibility in later life, but further studies are required. In adulthood there are a number of factors that are able to modify and compromise mucosal immunocompetence. These include nutritional status, infection, and stress, both psychological and physical. In the elderly the acquired mucosal immune response remains competent, although there is some loss of innate defenses.
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    Book Title
    Handbook of Mucosal Immunology
    DOI
    https://doi.org/10.1016/B978-0-12-415847-4.00011-2
    Subject
    Autoimmunity
    Innate immunity
    Immunology not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/136597
    Collection
    • Book chapters

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